摘要
目的 探讨前列地尔和肾康联合对调整慢性肾功能衰竭（CRF）患者肾功能和血脂水平的效果.方法 选择98例CRF患者为研究对象,采用1：1随机对照双盲实验的分组原则分为研究组与对照组（各49例）,两组给予优质低蛋白、低脂低盐饮食、控制感染、利尿消肿,纠正酸中毒、降压、纠正电解质平衡失调等常规治疗,治疗组在常规治疗的基础上应用前列地尔注射液20 μg＋ 100 ml生理盐水,静脉滴注1次/d;肾康注射液100 ml＋ 5％葡萄糖溶液300 ml,静脉滴注1次/d.对照组在常规治疗的基础上加用川芎嗪200 mg＋5％葡萄糖注射液250 ml,静脉滴注1次/d.两组疗程均为14 d.比较两组治疗前后肾功能、脂代谢、药物不良反应等.结果 治疗前两组肾功能差异无统计学意义（P均＞0.05）,治疗后研究组与对照组血肌酐[（313.7±66.2）、（358.4±53.9） μmol/L]、尿素氮[（15.3±2.9）、（18.4±3.0） mmol/L]、24h尿蛋白[（1.24±0.45）、（1.57±0.39） g/24 h]、内生肌酐清除率（Ccr）[（35.7±5.4）、（28.4±4.3） mmol/L]差异均有统计学意义（t值分别为3.754、7.864、5.873、7.864,P均＜0.05）.治疗前两组血脂差异无统计学意义（P均＞0.05）,治疗后研究组与对照组甘油三酯[（2.12±1.26）、（2.32±1.34） mmol/L]、总胆固醇[（4.91±1.43）、（5.35±1.31） mmol/L]、高密度脂蛋白胆固醇[（1.39±0.43）、（1.23±0.37） mmol/L]、低密度脂蛋白胆固醇[（2.39±0.68）、（2.73±0.88）mmol/L]差异均有统计学意义（t值分别为3.876、4.661、5.387、8.543,P均＜0.05）.两组治疗过程均无药物不良反应产生.结论 前列地尔、肾康注射液联合可显著改善患者的肾功能、脂代谢紊乱等,未发现明显的不良反应,值得临床广泛应用.
Objective To investigate efficacy in Alpmstadil and Shenkang on regulating renal function and lipids in patients with chronic renal failure （CRF）.Methods Ninety-eight cases of CRF patients were collected for the study,and 1：1 randomized,double-blind experiment grouping principles were used in the current study.All cases were divided into study group and the control group （49 cases of each group）.The two group were given the high quality low protein,low fat low salt diet,inftion control,diuretic swelling,correct acidosis,buck,correction of electrolyte imbalance and other conventional treatment.The patients in study group on the basis of conventional therapy were given 20 g Alprostadil injection ＋ 100 ml saline,intravenous infusion of 1times/d,and 100 ml Shenkang injection ＋300 ml 5% glucose the solution,intravenous infusion of 1 times/d.While patients of control grrup on the basis of conventional therapy plus 200 mg Ligustrazine ＋ 250 ml 5%Glucose Injection,intravenous infusion of 1times/d.Two groups were treated for 14 d.Before and after treatment,renal function,lipid metabolism,adverse drug reactions were observed and determined.Results There was no significant difference in term of renal function between two groups before treatment（P 〉 0.05）.After treatment,the levels of serum creatinine,blood urea nitrogen,24 h-Urine protein and creatinine clearance（Ccr） in study group were （313.7 ±66.2） mmol/L,（15.3 ±2.9） mmol/L,（1.24 ±0.45） g/24 h and （35.7 ±5.4） mmol/L respectively,significant different from those in control group （（358.4 ± 53.9） mmol/L,（18.4 ± 3.0） mmol/L,（1.57 ±0.39） g/24 h and （28.4 ±4.3） mmol/L;t =3.754,7.864,5.873,4.312,P 〈0.05）.There was no significant difference in term of blood fat between two groups before treatment （P 〉 0.05）.In study group,the levels of glycerin trilaurate,cholesterol total,high density hpoprotein cholesterol,low density lipoprotein cholesterol were significantly different than those in the control grou
出处
《中国综合临床》
2014年第12期1303-1306,共4页
Clinical Medicine of China
