摘要
目的观察老年局部中晚期直肠癌患者根治术后放疗联合卡培他滨化疗的临床疗效及不良反应。方法老年局部中晚期直肠癌根治术后患者52例分成2组，其中放疗联合常规化疗组（对照组）22例，放疗联合卡培他滨口服化疗组（实验组）30例。对照组化疗采用LV方案，实验组化疗采用卡培他滨单药口服方案，2组放疗方案相同，剂量均为DT45Gy／25次，5～6周。结果实验组局部复发率（16．7％）与对照组（18．2％）的差异无统计学意义（P〉0．05）。实验组远处转移率（30．0％）与对照组（36．4％）的差异无统计学意义（P〉0．05）。实验组1年生存率（83．3％）与对照组（81．8％）的差异无统计学意义（P〉0．05）。实验组4年生存率（46．7％）与对照组（45．5％）的差异无统计学意义（P〉0．05）。实验组放化疗不良反应发生率除手足综合征较高外，在恶心呕吐、腹泻、血细胞下降等各方面均低于对照组（P〈0．05）。结论卡培他滨单药化疗代替术后常规化疗方案，联合放疗治疗老年中晚期直肠癌术后患者可显著降低不良反应发生率，增加患者耐受性，且不降低疗效，值得临床推广。
Objective To observe the efficacy and adverse effects of postoperative radiotherapy combined with capecitabine in elderly patients with locally advanced rectal cancer. Methods A total of 52 elderly patients with locally advanced rectal cancer were divided into a control group in which 22 patients received routine chemotherapy combined with radiotherapy and a treatment group in which 30 patients were given radiotherapy combined with capecitabine. The LV scheme was adopted in the control group, while carpecitabine was orally taken in the treatment group. Both groups used a dose of DT 45 Gy/25f/5w during radiotherapy. Results The local recurrence rate of the treatment group （ 16.7% ） was not statistically different from that of the control group （ 18.2% ）. The distal metastasis rate was 30% in the treatment group and 36.4% in the control group, without statistical significance. The one -year survival rate of the treatment group （83.3%） was not statistically different from that of the control group （81.8%）. The four - year survival rate was 46.7% in the treatment group and 45.5% in the control group, without statistical significance. Compared with the control group the treatment group presented less adverse reactions including nausea, vomiting, diarrhea and reduced blood cell count, except hand - foot syndrome. Conclusion Capecitabine, instead of routine chemotherapy, combined with radiotherapy can provide the same efficacy but improve tolerance and significantly decrease adverse effects, which is worthy of widely clinical application.
出处
《徐州医学院学报》
CAS
2014年第11期814-816,共3页
Acta Academiae Medicinae Xuzhou
关键词
直肠癌
术后
卡培他滨
放疗
rectal cancer
post - operation
capecitabine
radiotherapy
