摘要
目的:探讨C-反应蛋白(C-reactive protein,CRP)、白细胞介素-6(Interleukin-6,IL-6)等炎症标志物在急性冠脉综合征(Acute coronary syndrome,ACS)及心脏事件发生中的预测价值。方法:监测92名ACS患者在住院及随访过程中血CRP、IL-6浓度变化并探讨其ACS、心脏不良事件发生之间的内在联系。结果:ACS患者CRP、IL-6浓度较对照组明显增高,二者相关性良好(r=0.67,P<0.01),经治疗后显著下降(P<0.01);住院及随访期间,发生心脏事件患者CRP、IL-6浓度显著高于未发生组,差异均有统计学意义(P<0.01);CRP在住院和随访期间对心脏不良事件预测的敏感度/特异性为:90.7%/79.6%、88.9%/80.9%;IL-6在住院和随访期间对心脏不良事件预测的敏感度/特异性为:85.9%/82.7%、84.2%/85.0%。结论:炎症反应与ACS的发生、发展有关,监测血中CRP、IL-6等炎症标志物的水平对ACS诊断、预后评估及中、近期心脏事件发生有较高的预测价值。
Objective ：To investigate the value of serum C‐reactive protein （CRP） and interleukin‐6 （IL‐6） in predic‐ting diseases in patients with acute coronary syndrome （ACS） and cardiac events .Methods ：92 patients with ACS were recruited in this study .The concentration changes of serum CRP and IL‐6 were noted .Results ：The levels of serum CRP and IL‐6 in patients with ACS were significantly higher than the control group ,with a good correlation （r= 0 .67 ,P＆lt;0 .01） ,decreased after treatment （P＆lt; 0 .01） .The levels of serum CRP and IL‐6 in patients with cardiac events were significantly higher than that without cardiac events for inpatients and patients followed up for 12 months（P＆lt; 0 .01） . The sensitivity and specificity of CRP in predicting adverse cardiac events were 90 .7% and 79 .6% for inpatients ,and 88 .9% and 80 .9% for patients followed up for 12 months .The sensitivity and specificity of IL‐6 were 85 .9% and 82.7% for inpatients ,and 84 .2% and 85 .0% for patients followed up for 12 months .Conclusion ：Inflammatory reac‐tion is correlated with ACS .The concentration of serum CRP and IL‐6 are important in the diagnosis ,treatment ,prog‐nosis of cardiac events for the patients ACS .
出处
《医学理论与实践》
2014年第24期3259-3260,3266,共3页
The Journal of Medical Theory and Practice
