摘要
早在公元前100年，Celsius就提到瘢痕癌变，1828年法国医师Marjolin描述了l例烧伤后瘤样瘢痕溃疡的详细特征，而后学术界将瘢痕恶变创面取名为“马乔林溃疡”并沿用至今。迄今为止对瘢痕癌治疗中的某些问题还未达成共识。本文就瘢痕癌的相关研究进展进行综述，以期为临床合理治疗提供参考。
Marjolin＇s ulcer is a rare malignancy arising from various forms of scars,mainly an old scar resulted from burn.The second most common origin is malignant degeneration arising from tissue within osteomyelitis fistulae.Not uncommonly,the lesions may arise secondary to ulcers due to venous insufficiency or pressure sores.The pathology of the majority of Marjolin＇s ulcer is a well-differentiated squamous cell carcinoma.The exact reason for an ulcer which undergoes a malignant transformation is unknown.The pathologic diagnosis is the gold standard.Surgery remains the preferred treatment after diagnosis is reached.Wide surgical excision with margins up to 2-3 cm has been suggested.The necessity of whether lymphatic dissection should be executed,or radiotherapy and chemotherapy following surgery is still in dispute.This article deals with the etiology of Marjolin＇s ulcer and its pathological grading,diagnosis,treatment,prognosis,and prevention,with a hope to provide some useful clinical information.
出处
《中华烧伤杂志》
CAS
CSCD
北大核心
2014年第6期495-499,共5页
Chinese Journal of Burns
关键词
烧伤
皮肤
瘢痕
癌
Burns
Skin
Cicatrix
Carcinoma
