摘要
支原体是引起人类多种疾病的微生物,常常寄居于人体细胞、组织中。通过细胞生长曲线、粘附实验、抗饥饿实验、抗氧化实验及Western blot方法,初步探讨了发酵支原体糖基转移酶对哺乳动物细胞的影响。结果表明,支原体糖基转移酶对细胞生长没有太大的影响,但是抑制了细胞粘附及抗氧化能力,促进了细胞的抗饥饿能力。将有助于让人们更深入地了解支原体如何引起人类及其它哺乳动物多种疾病的细胞和分子机制。
Mycoplasmas are those microorganisms that inhabit human cells and tissues, and cause some kinds of dis- eases. This study investigated the effects of Mycoplasma fermentans glycosyhransferase on mammalian cell lines by tests of cell proliferation, adhesion, anti-starvation, anti-oxidization and the assays of Western blot. The results in- dicate that mycoplasmal glycosyltransferase has no apparent effect on cell proliferation, but inhibits cell adhesion and anti-oxidization ability, and promotes the cellular ability of anti-starvation. This study is helpful for people to understand deeply the cellular and molecular mechanisms of diseases caused by mycoplasmas.
出处
《武汉轻工大学学报》
CAS
2014年第4期27-31,共5页
Journal of Wuhan Polytechnic University
关键词
发酵支原体
糖基转移酶
细胞增殖
细胞粘附
抗饥饿
Mycoplasma fermentans
glycosyltransferase
cell proliferation
cell adhesion
anti-starvation
