摘要
目的探讨组织蛋白酶B(Cat B)和胱抑素C(Cys C)在中耳胆脂瘤组织中的表达及临床意义。方法免疫组织化学SP法检测45例胆脂瘤标本(A组)和18例正常外耳道皮肤标本(B组)中Cat B和Cys C的表达。结果与B组比较,A组Cat B呈高表达,Cys C呈低表达。胆脂瘤中Cat B和Cys C的表达呈负相关(r=-0.318,P<0.05)。结论 Cat B高表达与中耳胆脂瘤骨破坏作用相关,Cys C通过抑制Cat B阻止骨破坏过程。
Objective To stady the expressions and significance of cathepsin B（Cat B） and cystatin C （Cys C） in middle ear cholesteatoma. Methods Immunohistochemical SP method was used to detect the expressions of Cat B and Cys C in 45 cholesteatoma samples（group A） and 18 normal external ear canal skin specimens（group B）. Results Compared to group B, Cat B expression was higher,but Cys C expression was lower, in group A（P〈0. 05）. Cat B expression was negatively correlated to Cys C expression in the cholesteatoma （r=-0. 318, P〈0. 05）. Conclusion High expression of Cat B is associated with middle ear bone destruction by cholesteatoma. Cys C prevents bone destruction process by inhibiting Cat B expression.
出处
《江苏医药》
CAS
北大核心
2014年第23期2848-2850,共3页
Jiangsu Medical Journal
