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实时光电探测系统与人乳头瘤病毒检测在意义不明的不典型鳞状上皮细胞病例中的诊断价值对比 被引量:1

Comparative study of diagnostic efficacy between truscreen cervical cancer screening system and human papilloma virus test on ASC-US cases
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摘要 目的探讨实时光电探测系统(Truscreen Cervical Cancer Screening system,TS)与人乳头瘤病毒检测(Human papilloma virus,HPV)在液基薄层细胞学检测(Thinprep-liquid-based cytological test,TCT)提示意义不明的不典型鳞状上皮细胞(Atypical squamous cells of undetermined significance,ASCUS)中的诊断效果对比。方法对于243例TCT提示ASCUS的病例,以阴道镜下病理学结果为金标准,比较TS及HPV的灵敏度、特异度及ROC(Receiver operator characteristic curve,ROC)曲线下面积。结果 243例病例中,TS、HPV的灵敏度分别为74.2%、47.6%,特异度分别为77.6%、84.9%;比较ROC曲线下面积,TS与HPV差异有统计学意义(P<0.05)。结论本研究中,对于TCT提示ASCUS的病例,TS的诊断效果优于HPV,临床上可考虑用TS作为对细胞学提示ASCUS病例的确认检测方法之一。 Objective To study the diagnostic efficacy of Truscreen Cervical Cancer Screening system( TS) compared with Human papilloma virus test( HPV) on patients whose Thinprep-liquid-based cytological test( TCT) showed Atypical squamous cells of undetermined significance( ASCUS). Methods 243 cases of patients whose TCT showed ASCUS were screened by TS,HPV based on the pathology and colposcopy results as a golden standard. To compare the sensitivity,specificity and the area of under ROC of each method. Results The sensitivity of TS,HPV were 74. 2%,47. 6%,the specificity were 77. 6%,84. 9%. Contrasting the areas of under ROC,there were significant differences between TS and HPV( P 0. 05). Conclusions In this study,contrasting diagnosis effect on patients whose TCT showed ASCUS,TS was better than HPV. For the cases whose cytological test showed ASCUA,TS has potential to be used as a confirmatory detective method in clinical practice.
出处 《中国妇幼卫生杂志》 2014年第6期23-25,29,共4页 Chinese Journal of Women and Children Health
基金 广东省科技厅课题<TruScreen联合宫颈巴氏涂片在宫颈癌筛查中的作用> 编号:83061
关键词 实时光电探测系统 人乳头瘤病毒检测 意义不明的不典型鳞状上皮细胞 诊断效果 truscreen cervical cancer screening system human papilloma virus test atypical squamous cells of undetermined significance diagnostic efficacy
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