摘要
目的:利用计算机模拟的方法分析重组抗肿瘤抗病毒蛋白(乐复能)的抗病毒及抗肿瘤活性优于普通干扰素(IFNα-2b)的机制。方法:通过对乐复能、乐复能与干扰素受体形成复合物的结构预测,分析乐复能与其受体的相互作用。结果:与IFNα-2b相比较,乐复能和受体IFNR1的相互作用力有了明显的提高,结合更加紧密。结论:计算机模拟的方法可以有效地应用于尚无晶体信息的蛋白类药物及其与受体相互作用的结构预测。
Objective： To analyze the mechanism of the superior activities of recombinant antitumor - antivirus pro- tein（novaferon） to those of IFNα -2b by using computer simulation. Methods：The structures of novaferon and the novaferon -receptor complex were predicted in order to study the mutual interaction of novaferon and its receptor. Results：The mutual interaction force of novaferon and IFNR1 was improved obviously compared with IFNα -2b, and the conjunction was tighter. Conclusion：The method by computer stimulation can be effectively applied to the structure prediction of protein drugs interacting with their receptors which had no clear crystal information.
出处
《药物分析杂志》
CAS
CSCD
北大核心
2014年第12期2124-2127,共4页
Chinese Journal of Pharmaceutical Analysis
基金
国家科技重大专项课题(2012ZX09304010)资助
关键词
蛋白类药物
乐复能
干扰素
抗肿瘤活性
抗病毒活性
结构预测
生物信息学
计算机模拟方法
protein drugs
novaferon
interferon
antitumor activity
antiviral activity
structure prediction
bioinfor- matics
computer simulation method
