摘要
目的:探讨不同治疗方法对特发性中枢性性早熟(ICPP)女童初潮年龄及成年终身高的影响。方法:回顾性分析2007年12月底前明确诊断,且2013年12月底前达到终身高的84例ICPP女童的临床及随访资料,其中未治疗组41例(A组);单用促性腺激素释放激素类似物(GnRHa)治疗组28例(B组);GnRHa联合生长激素(rh GH)治疗15例(C组)。比较3组女童研究之初、治疗结束时终身高以及初潮年龄的差异。结果:3组患儿治疗前身高无统计学差异(F=0.51,P>0.05)。3组的成年终身高分别为(150.06±2.33)cm,(155.35±2.42)cm和(156.75±2.15)cm,B、C两组均显著大于A组(t=9.02,P<0.01;t=9.70,P<0.01),但B组和C组间未发现统计学差异(t=1.88,P=0.07)。未治疗组的身高净获为(-1.89±3.03)cm,显著低于B组和C组(P<0.05),C组大于B组(P<0.01)。A组月经初潮年龄小于B组和C组女童。结论:对ICPP患儿给予GnRHa治疗是有效和必要的,能够有效推迟女童的月经初潮年龄,增加患儿的成年终身高;两药联用对终身高的改善有一定的效果。
Objective： To explore the effects of different therapeutic methods on menarche age and final adult height of girls with idiopathic central precocious puberty（ ICPP）. Methods： The clinical and follow- up data of 84 girls diagnosed as ICPP definitely before the end of December in 2007 and reaching their final adult height before the end of December in 2013 was analyzed retrospectively,then the girls were divided into group A,group B and group C,41 girls in group A did not receive any treatment,28 girls in group B were treated with gonadotropin releasing hormone analogue（ GnRHa）,15 girls in group C were treated with GnRHa combined with recombinant human growth hormone（ rh GH）. The final adult heights and menarche ages at the beginning and at the end of the study in the three groups were compared. Results： There was no statistically significant difference in body height before treatment among the three groups（ F = 0. 51,P〈0.05）. The final adult heights of girls in the three groups were（ 150. 06 ± 2. 33） cm,（ 155. 35 ± 2. 42） cm and（ 156. 75 ± 2. 15） cm,respectively,the final adult heights of girls in group B and group C were statistically significantly higher than that in group A（ t = 9. 02,P〈0.01; t = 9. 70,P〈0.01）,but there was no statistically significant difference between group B and group C（ t = 1. 88,P = 0. 07）. The net height gain in group A was（- 1. 89 ± 3. 03） cm,which was statistically significantly lower than those in group B and group C（ P〈0.05）; the net height gain in group C was statistically significantly higher than that in group B（ P〈0.01）. The menarche age in group A was younger than those in group B and group C. Conclusion： GnRHa therapy is effective and necessary for ICPP girls,which can effectively delay menarche age and increase final adult height; GnRHa combined with rh GH has a certain impact on improving final adult height.
出处
《中国妇幼保健》
CAS
北大核心
2014年第36期6032-6034,共3页
Maternal and Child Health Care of China
基金
浙江省卫生厅医药卫生项目〔2011zha013〕
关键词
特发性中枢性性早熟
促性腺激素释放激素类似物
重组人生长激素
初潮年龄
终身高
Idiopathic central precocious puberty
Gonadotropin releasing hormone analogue
Recombinant human growth hormone
Menarche age
Final adult height
