摘要
目的:研究3种不同药物方案治疗幽门螺杆菌(Helicobacter Pylor,HP)的根除疗效及经济成本。方法:180例HP患者随机分成A、B、C 3组,A组给以替那拉唑10mg+阿莫西林1000mg+克拉霉素500mg;B组给以兰索拉唑10mg+呋喃西林100mg+卡那霉素500mg;C组给以胶体果胶铋200mg+培氟沙星200mg+羧苄西林1000mg;3组均口服,2次/日,疗程均为7天。治疗4周后胃镜复查和14C呼气试验,比较根除率,并对成本效果比(C/E)和增量成本-效果比(△C/△E)分析。结果:ITT分析和PP分析根除率,发现C组与A、B组相比较差异有统计学意义(P<0.05);ITT和PP分析C/E,证明C组所需成本最低,且相对于A组,C组△C/△E较B组低,表明在同等疗效前提下所需的成本较小。结论:胶体果胶铋、培氟沙星、羧苄西林药物联用疗法更符合理想的HP根除方案要求,高效、安全、经济,适用于临床应用。
Objective]To study the clinical efficacy and economic cost of three drug treatment projects ofhelicobacter pylori （HP） eradication .[Method]One hundred and eighty HP patients were randomly divided into three groups ,group A ,group B and group C .10 mg tenprazole and 1000 mg amoxicillin （Huameihua , Wuhan ） and 500 mg clarithromycin were applied in group A ,10 mg lansoprazole and 100 mg furacilin and 500 mg kanamycin were applied in group B ,200 mg colloidal bismuth pectin and 200 mg pefloxacin and 1000 mg carbenicillin were applied in group C ,which were took via orally twice a day and all the times of therapy were 7 days;Stomachoscopy gastroscopy and 14C-urea breath test were applied to compare the elimina-tion rate 4 weeks after drug treatment .C/E and△C/△E were evaluated .[Result]Eradication rates analyzed by ITTand PP demonstrated group C were obviously higher than groups A and B （ P＆lt;0.05 ） .C/E revealed by ITT and PP demonstrated the cost of group C was lowest .The smaller value of △C/△E in group C suggested a lower cost under the precondition achieving equivalent efficacy ,using the group A as control .[Conclusion ]Combination of colloidal bismuth pectin , pefloxacin and car-benicillin was more suitable as the ideal project on HP eradication in clinical ,which was proved to be effective ,safe and eco-nomical .
出处
《浙江医学教育》
2014年第5期24-26,共3页
Zhejiang Medical Education
关键词
幽门螺杆菌
根除率
经济成本
Helicobacter Pylori
eradication rate
economic cost
