IL-13单克隆抗体治疗支气管哮喘被引量：2

The treatment of anti-IL-13 monoclonal antibody in bronchial asthma

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摘要 IL-13是Th2细胞因子的-种，是免疫炎症反应主要的调节因子，在支气管哮喘（简称哮喘）的发生发展中起重要的作用。本文将对IL-13在哮喘病理生理中的作用进行概括，并对近年来IL-13单克隆抗体（IL-13单抗）治疗哮喘的研究进行总结，重点对IL-13单抗的作用机制、有效性、安全性及目标人群进行概括和总结。 Interleukin-13 （IL-13） is one of the Th2 cytokine, it is a critical regulator of inflammatory immune responses,with key roles in the pathogenesis and development of asthma. Here,we will summarize the role of IL-13 in asthma and the treatment of anti-IL-13 monoclonal antibody（anti IL-13 mAb） in asthma in recent years, focusing on the mechanism, efficacy, safety and target population of anti-IL-13 mAb.

作者郝济敏时国朝

机构地区上海交通大学医学院附属瑞金医院呼吸科

出处《国际呼吸杂志》 2014年第23期1799-1802,共4页 International Journal of Respiration

关键词 IL- 13 单克隆抗体哮喘 Anti-IL-13 monoclonal antibody Asthma

分类号 R737.11 [医药卫生—肿瘤]

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