摘要
在运动科学领域中,研究者通过测定分别产生IFN-γ(或IL-2)与IL-4的外周血、脾脏细胞计数(或百分比),脾脏与外周血细胞在培养与刺激条件下分泌Th1、Th2类细胞因子的水平,以及血液中相关细胞因子含量的方法,从细胞数量与功能上来评价运动中机体的免疫平衡状态。分析认为:(1)Th1、Th2细胞在运动中的变化趋势分别与Tc1、Tc2细胞保持一致,Th1/Th2平衡能间接反映T1/T2平衡的变化。(2)相比细胞数量,细胞因子可能更能有效评价运动中的Th1/Th2平衡。(3)通过淋巴细胞分泌的相关细胞因子水平来评价运动中Th1/Th2平衡时,刺激物等实验条件可影响实验结果。(4)循环血中IFN-γ、IL-4的含量可用于间接评定运动中的Th1/Th2平衡。通过对运动中Th1/Th2平衡评价方法的分析与评述,以期为未来相关研究的设计提供依据,为其成果内容的表述提供参考。
In the field of sports science, the number/percentage of IFN-γ （or IL-2） and IL-4 cells in periph-eral blood or spleen, the levels of Th1, Th2-associated cytokines produced by the cells, and the concentrations of the cytokines in circulation are measured by researchers to evaluate the Th1/Th2 balance following exercise from the per-spective of Th1and Th2 cell numbers and function. The analysis believes that （1） The change of Th1 and Th2 cells in response to exercise is the same as that of Tc1 and Tc2 cells respectively, while Th1/Th2 balance can be used as the in-dicator of T1/T2 balance indirectly. （2） The concentration of cytokines may be the more meaningful indicators of Th1/Th2 balance in response to exercise than that of cell numbers. （3） The concentration of cytokines in the circulation may be the more meaningful indicators of Th1/Th2 balance in response to exercise than that of cytokines produced by lymphocytes. The review is to provide the basis for study protocols and reference for discussions in the future researches through the reflection on the evaluation of Th1/Th2 balance in response to exercise.
出处
《成都体育学院学报》
CSSCI
北大核心
2014年第12期79-84,共6页
Journal of Chengdu Sport University
基金
江西省自然科学基金项目(2011ZBAB204028)
