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老年肥胖和骨质疏松 被引量:5

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摘要 传统观念认为,超重和肥胖对骨具有保护作用,有利于抗骨质疏松,而低体质量则是骨量减少的危险因素。肥胖者骨密度(BMD)比较高的原因包括:骨骼承受的机械负荷一方面通过Wnt/β-catenin信号通路,促进成骨细胞增殖分化,从而刺激成骨;另一方面通过调节核因子-κB(NF-κB)受体激活物配基(RANKL)/护骨素(OPG)系统,抑制破骨细胞分化,从而减少骨吸收。
作者 贾红蔚 朱梅
出处 《实用老年医学》 CAS 2014年第11期887-890,共4页 Practical Geriatrics
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