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胺碘酮联合依那普利对慢性心力衰竭合并阵发性房颤的临床观察 被引量:5

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摘要 目的探讨胺碘酮联合依那普利对慢性心力衰竭合并阵发性心房颤动的临床效果。方法 144例慢性心力衰竭合并阵发性心房颤动患者随机分为两组,均使用胺碘酮维持窦性心律,治疗组在此基础上加用依那普利,治疗1年后,观察和比较两组患者慢性心力衰竭住院率,心房颤动复发率,左心室射血分数、左心室舒张末期内径及B型脑钠肽情况。结果治疗组心房颤动复发率达12.5%、慢性心房颤动发生率达6.9%,显著低于对照组的29.2%和23.0%(P<0.05);治疗组左心室射血分数、左心室舒张末期内径及B型脑钠肽情况改善显著,与治疗前及治疗后对照组比较,差异均具有统计学意义(P<0.05)。两组不良反应(如甲状腺功能异常、视力下降、肺纤维化、咳嗽和低血压)的发生率比较差异无统计学意义(P>0.05)。结论胺碘酮联合依那普利对慢性心力衰竭合并阵发性心房颤动能较好维持窦性心律,对心脏的重构有较好的改善作用,提高患者生存质量,具有较好的安全性。
作者 刘志宽
出处 《中国实用医药》 2014年第31期158-159,共2页 China Practical Medicine
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