摘要
目的 :研究酒精性肝硬化病人白细胞介素 6及其与白细胞介素 2相关性。方法 :应用ELISA方法分别检测了酒精性肝硬化病人血清白细胞介素 6 (IL - 6 )及外周血单核细胞 (PBMC)自然和诱导产生的IL - 6和IL - 2水平 ,同时观察了诱导产生的IL - 6与免疫球蛋白IgA、IgG及IL - 2的相关性。结果 :血清中和PBMC自然或诱导产生的IL - 6均明显高于健康对照组 ,IL - 6与血清IgA水平呈正相关 ,与IL - 2呈负相关。结论
Objective:Study on interleukin-6levels and the correlation with interleukin-2 level in alcoholic liver cirrhosis.Methods: In order to explore the pathogenesy of alcoholic liver cirrhosis. The serum levels and spontaneous or induced production of IL-6 by peripheral blood monoclonal cells has been studied by ELISA in alcoholic liver cirrhosis. At the same time we examined IL-2 level by PBMC and observed the correlation of IL-6 with IgA,IgG serum levels and IL-2. Results:The result show that serum levels and spontaneous or induced prodouction of IL-6 by PBMC are increased.IL-6 Production correlates closely with the IgA serum levels and negatively with impaired IL-2. Conclusions: abnormality of levels of interleukin in patients with alcoholic liver cirrhosis could be realted to overproduction of immunoglobulins and disbalance observed in this disease.
出处
《中国厂矿医学》
2002年第4期268-270,共3页
Chinese Medicine of Factory and Mine
