摘要
目的:了解糖耐量正常(NGT)人群中行75 g口服葡萄糖耐量(75 g OGTT)后1 h血浆血糖(1-h PG)水平与空腹血脂谱之间的相关关系。方法:选择合肥市郊区4个社区40岁以上常住居民为研究对象,根据75 g OGTT检查结果,共筛选出6 402例NGT。再依据随机数据表法随机抽取1 291例NGT作为本研究对象。根据1-h PG水平,分为NGT-1组(1-h PG<8.6 mmol/L)和NGT-2组(1-h PG≥8.6 mmol/L),两组受试者人数分别为597和694例。应用Pearson相关分析以及多元线性回归分析了解1-h PG与空腹血脂谱之间的相关关系。结果:(1)NGT-1组、NGT-2组中平均体质指数分别为24.3和24.5 kg/m2。(2)与NGT-1组相比,NGT-2组受试者的空腹血糖、OGTT后2 h血糖、糖化血红蛋白、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-c)、TG/HDL-c、总胆固醇(TCH)/HDL-c均显著升高(P<0.05)。(3)Pearson相关分析以及多元线性回归分析显示,无论在NGT-1组还是NGT-2组中,1-h PG与TG均呈正相关(P<0.01),与HDL-c均呈负相关(P<0.01)。结论:在NGT的超重人群中,75 g OGTT后1 h PG水平与空腹HDL-c、TG水平密切相关。
Objective To examine the association between one-hour plasma glucose （1-hPG） level during an oral glucose tolerance test （OGTT） and serum lipid profiles in individuals with NGT. Methods 6 402 individuals with NGT who underwent a 75 g OGTT were screened from four communities of Hefei suburban areas, aged over 40 years. Then 1 291 cases of NGT were randomly selected as the object of this research by random data table method. They were divided into NGT-1 group （1-h PG 〈 8.6 mmol/L, n = 597）and NGT-2 group（1-h PG≥8.6 mmol/L, n = 694）. Pearson correlation analysis and multivariate linear regression analyses were performed to assess correlations between 1-h PG levels and lipid profiles. Results （1） The average values of body mass index were 24.3 kg/m2 in NGT-1 group, and 24.5 kg/m2 in NGT-2 group. （2） Compared with individuals in NGT-1 group , fasting plasma glucose , two-hour plasma glucose during OGTT , HbA1c , triglyceride （TG）, and high-density lipoprotein-cholesterol（HDL-c） levels, TG/HDL-c ratios, and total cholesterol（TCH）/HDL-c ratios were significantly higher in individuals than in NGT-2 group. By contranst, body mass index, blood pressure , TCH and low-density lipoprotein-cholesterol levels were not significantly different between NGT-1 group and NGT-2 group. （3） The multiple linear regression analyses showed that 1 h PG levels positively correlated with TG in individuals in both NGT-1 group and NGT-2 group （P 〈 0.01）. In addition, 1-h PG levels negatively correlated with HDL-c ratio in both groups （P 〈 0.01）. Conclusion 1-h PG levels during OGTT in overweight individuals with NGT closely correlate with HDL-c and TG levels.
出处
《实用医学杂志》
CAS
北大核心
2014年第23期3765-3768,共4页
The Journal of Practical Medicine
基金
中华医学会临床科研专项基金(编号:12020320322)
关键词
口服葡萄糖耐量试验
1h血糖
甘油三酯
高密度脂蛋白胆固醇
超重
Oral glucose tolerance test
One-hour plasma glucose level
Triglyceride
High-density lipoprotein-cholesterol
Overweight
