摘要
目的：探讨强心利尿剂治疗顽固性心力衰竭的疗效。方法选择36例经常规强心、利尿、扩血管[洋地黄、磷酸二酯酶抑制剂、转换酶抑制剂（ACEI）、速尿]等治疗无效的顽固性心力衰竭患者应用多巴胺、多巴酚丁胺、硝酸甘油、氨茶碱、托拉塞米等小剂量针剂组成的强心利尿剂进行治疗。结果显效（由心功能Ⅳ级减轻到～Ⅱ级）25例，有效（心功能Ⅳ级减轻到Ⅱ～Ⅲ级）7例，无效（心衰症状无明显改变）4例。治疗前后心率、血流动力学、左室射血分数（LVEF）、左室收缩末径（LVESD）等指标比较差异均有统计学意义（ P＜0.01）。结论多巴胺、多巴酚丁胺、硝酸甘油、氨茶碱、托拉塞米组成的小剂量强心利尿剂治疗顽固性心力衰竭效果好。
Objective To investigate the curative effect of cardiotonic and diuretic mixture in the treatment of refractory heart failure .Methods Thirty-six refractory heart failure patients who had not response to conventional cardiac, diuretic, vasodilator （digitalis, phosphodiesterase inhibitors , ACEI, furosemide and so on） were treated by cardiotonic and diuretic mixture composed of small dose of dopamine , dobutamine , nitroglycerin , aminophylline , to-rasemide injection etc .Results The marked effect was found in 25 cases （ NYHA decreased from grade Ⅳ toⅠ~Ⅱ）, effectively in 7 cases（NYHA decreased from grade ⅣtoⅡ~Ⅲ）, no effect in 4 cases（heart failure symptoms had no obvious change ） .There were statistically significant differences in heart rate , hemodynamic left ventricular e-jection fraction（LVEF）, left ventricular end-systolic diameter（LVESD） and other indicators before and affer treat-ment（P〈0.01）.Conclusion The cardiofonic diuretic mixture composed of dopamine , dobutamine, nitroglycerin,＆amp;nbsp;aminophylline, torasemide injection etc has marked effect in treating refractory heart failure patients who had not re -sponse to conventional cardiotonic and diuretic therapy .
出处
《中国临床新医学》
2014年第11期1050-1052,共3页
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
关键词
强心利尿剂
顽固性心力衰竭
疗效观察
Cardiotonic and diuretic mixture
Refractory heart failure
Curative effect observation
