摘要
目的研究人脑胶质瘤的电阻抗特性并建立其等效电路,可为进一步区分人脑胶质瘤和正常脑组织的阻抗特性差异提供依据。方法利用英国Solartron公司的阻抗分析仪(1260),采用四端法,在10Hz^10 MHz范围内,对4例体外人胶质瘤组织进行电阻抗测量。通过分析其频率特性并结合已有的人脑组织的等效电路,建立了体外胶质瘤的等效电路,利用阻抗分析软件Z-VIEW对其进行仿真。结果体外人脑胶质瘤的阻抗模值在10 Hz^10 MHz范围内随频率的增大而下降,相位角在该范围内随频率的增大而增大。体外人脑胶质瘤组织在10 kHz^10 MHz范围内电阻抗实部比较稳定,其中在10Hz^10 kHz范围内,实部随频率的增大而减小。电阻抗虚部在20 kHz^10 MHz范围内较稳定,而在10Hz^20 kHz范围内,虚部随频率增大而增大。样本的等效电路仿真曲线与实际曲线相比较,等效电路模型能较好地反映体外人脑胶质瘤的电阻抗特性。结论体外人脑胶质瘤与已知的正常脑组织的电阻抗特性及等效电路差别明显,这为探索生物电阻抗技术应用于区别胶质瘤与正常脑组织的临床应用提供了研究基础。
Objective To study the electric impedance characteristics an.：l to build the equivalent circuit of human glioma tissues. This paper provides the fundamental evidence for the further research on bioelectrical impedance of human glioma tissues. Methods The measurements for the electric impedance of four human glioma tissues are done by using four-probe method in the frequency range of 10 Hz to 10 MHz with Solartron 1260 impedance analyzer. By analyzing the frequency characteristics and reference the existing equivalent circuits of human brain tissue, the equivalent circuit model of human glioma is established. Results Within the frequency range of 10 Hz to 10 MHz, the module of the electric impedance decreases and the phase angle increases along with the increase of the frequency. In the frequency range of 10 kHz to 10 MHz, the real part of the electric impedance remains steady. However, in the frequency range of 10 Hz to 10 kHz, it decreases along with the increase of the frequency. The imaginary part of the electric impedance remains steady in the frequency range of 20 kHz to 10 MHz and increases along with the increase of the frequency in the frequency range of 10 Hz to 20 kHz. This equivalent circuit model can describe the comprehensive characteristics of the complex impedance.Conclusions There are distinct differences of electric impedance characteristics and equivalent circuit between human glioma tissues and human brain tissues, which provide the basis for further research on the application of bioelectrical impedance in distinguishing human glioma tissues and human brain tissues.
出处
《北京生物医学工程》
2014年第4期387-392,438,共7页
Beijing Biomedical Engineering
基金
国家自然科学基金(81201988)
上海市科委基金(121409018021)
上海市学科带头人项目(10XD1401900)
上海市高校创新团队资助项目资助
关键词
人脑胶质瘤
电阻抗
等效电路
human glioma
electric impedance
equivalent circuit
