摘要
以4-雄烯二酮为原料,经羰基保护、双键卤羟化、水解脱保护三步反应合成了5α-氯-6β-羟基-雄甾-3,17-二酮。讨论了保护试剂、催化剂、卤羟化试剂、反应温度等对实验结果的影响,得出了较佳工艺条件,三步总收率达到88%。
Using 4-androstenedione as raw material, 5α-chloro-6β-hydroxy-androst-3,17-dione was synthesized via carbonyl protection, halogen hydroxylation of double bound and hydrolysis deprotection. The effect of protecting agent, catalyst, halogen hydroxylation agent and temperature were discussed. A better technological condition was obtained with the total yields of 88%.
出处
《浙江化工》
CAS
2014年第11期16-18,共3页
Zhejiang Chemical Industry
