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特发性尿钙增多症合并骨质疏松1例并文献分析

Analysis of a case of idiopathic hypercalciuria combined with osteoporosis,and a literature review
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摘要 特发性尿钙增多症(idiopathic hypercalciuria,IH)的概念由Albright[1]等人于1953年提出,指在正常钙摄入的情况下,排除各种继发因素,血钙正常,24小时尿钙〉4 mg/kg(0.1 mmol/kg)及尿Ca/Cr〉0.21即可诊断的一种疾病。临床上IH并不少见,有报道成人尿石症伴IH者达40%~60%,而小儿尿石症中仅2%~5%是由IH所致。但IH合并严重骨质疏松者少有报道,现将我院内分泌科1例IH合并骨质疏松报道如下。 Idiopathic hypercalciuria (IH) is a heterogenous disorder first described by Albright et al in 1953.It is characterized by normal blood calcium ( Ca) but excretion urinary Ca〉4 mg/kg in 24 hours ( normal 0.1 mmol/Kg) and urine Ca/Cr〉0.21 under normal Ca uptake and no secondary factors.IH is not few in the clinic.It is reported that in adults 40-60% of urolithiasis are associated with IH, while in children only 2-5% of urolithiasis are associated with IH.However, serious osteoporosis associated with IH is seldom reported.We report a case of IH combined with osteoporosis in the Department of Endocrinology of our hospital.
出处 《中国骨质疏松杂志》 CAS CSCD 北大核心 2014年第11期1350-1351,共2页 Chinese Journal of Osteoporosis
基金 2011年国家临床重点专科建设项目
关键词 特发性尿钙增多症 骨质疏松 Idiopathic hypercalciuria Osteoporosis
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参考文献4

  • 1Albright F, Hanneman PF, Benedict PH, et al. Idiopathic hypercalciuria. A preliminary report. Proc R Soc Med, 1953, 46 : 1077-1081. 被引量:1
  • 2Peris P, Guan abens N, Monegal A, et al. Aetiology and presenting symptoms in male osteoporosis. Br J Rheumatol, 1995, 34:936-41. 被引量:1
  • 3Zeliha Hekimsoy, MD, Sevinc Biberoglu, MD, Hatem Kazimoglu, et al. Bone Mineral Density and Biochemical Markers of Bone in Patients With Idiopathic Hypercalciuria. The Endocrinologist, 2003,13 : 417- 421. 被引量:1
  • 4Pak CY, Heller HJ, Pearle MS, et al. Prevention of stone formation and bone loss in absorptive hypercalciuria by combined dietary and pharmacological interventions. J Urol, 2003,169: 465 -469. 被引量:1

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