摘要
目的急支平喘软胶囊(简称JZ软胶囊)主要用于治疗急性支气管炎和慢性支气管炎急性发作。文中根据其功能主治,进行了镇咳、平喘、化痰药效研究。方法按随机数字列表法将小鼠分为5组(10只/组),镇咳对照组(等体积0.5%CMC-Na溶液),枸橼酸喷托维林片组(0.013 g/kg),JZ软胶囊镇咳高(16.38 g/kg)、中(8.19 g/kg)、低(2.73 g/kg)剂量组;观察JZ软胶囊的镇咳作用。另按随机数字列表法将豚鼠分为5组(10只/组),平喘对照组(等体积等渗盐水),氨茶碱组(0.025 g/kg)、JZ软胶囊平喘高(9.76 g/kg)、中(4.88 g/kg)、低(1.63 g/kg)剂量组,观察JZ软胶囊对哮喘潜伏期的影响。另外,按随机数字列表法将小鼠分为5组(10只/组),排痰对照组(等体积等渗盐水),氨茶碱组(0.025 g/kg)、JZ软胶囊排痰高(9.76 g/kg)、中(4.88 g/kg)、低(1.63 g/kg)剂量组;观察JZ软胶囊对排痰量的影响,评价其化痰作用。结果 JZ胶囊镇咳高、中、低剂量组咳嗽次数分别为(29.6±13.0)、(27.1±7.6)、(33.5±10.4)次/5 min,较镇咳对照组明显减少(P<0.05);JZ胶囊平喘高、中剂量组哮喘潜伏期分别为(77.2±13.3)s、(79.0±13.0)s,较平喘对照组明显延长(P<0.01);JZ胶囊排痰高、中剂量组气管酚红排出量分别为(1.75±0.70)μg/m L、(1.64±1.22)μg/m L,较排痰对照组明显增加(P<0.05)。结论急支平喘软胶囊具有一定的镇咳、平喘、化痰作用。
Objective Jizhipingchuan soft capsula is mainly used to treat acute bronchitis and acute attack of chronic bron-chitis.This paper investigate the antitussive, antiasthmatic and expectorant effects of Jizhipingchuan soft capsula according to its func-tions. Methods The antitussive effect of Jizhipingchuan soft capsula was observed in cough mouse model induced by ammonia and in guinea cough pig model induced by citric acid, and the latent period of asthma was observed in guinea pig induced by acetylcholine chloride and histamine phosphate.Its expectorant effect was evaluated by the excretion of phenol red in mice and the exudation phlegm in rats. Results Jizhipingchuan soft capsula could decrease the frequence of cough induced by ammonia in mice and induced by cit-ric acid in guinea pig.It could prolong the latent period of cough in guine pig and also prolong the latent period of asthma in guine pig induced by acetylcholine chloride and histamine phosphate.Jizhipingchuan soft capsula could significantly increase the amount of phe-nol red secreted in mice and the phlegm exudation of rats. Conclusion Jizhipingchuan soft capsula showed definite antitussive, an-tiasthmatic and expectorant effects.
出处
《医学研究生学报》
CAS
北大核心
2014年第11期1194-1196,共3页
Journal of Medical Postgraduates
关键词
急支平喘软胶囊
镇咳
平喘
化痰
Jizhipingchuan soft capsula
Antitussive
Antiasthmatic
Expectorant
