摘要
目的通过分析IVF－ET治疗后终止于生化妊娠与发展为临床妊娠两种结局患者之间的各相关因素，试图探讨生化妊娠发生的影响因素。方法对55例生化妊娠、100例同期临床妊娠患者的临床资料进行回顾性分析，采用非条件Logistic回归方法比较两组间的各暴露因素。结果男方年龄、原发／继发不孕、是否有自然流产史、降调方案、基础窦卵泡数、受精率是生化妊娠的显著影响因素（P〈0．05），是否有自然流产史，基础窦卵泡数是生化妊娠的独立影响因素。结论IVF-ET治疗中生化妊娠的发生受年龄、卵巢储备功能、超促排卵方案、是否有自然流产史等多因素影响的。
Objective To analyze various relevant factors that contribute to the development of the biochemical pregnancy or the clinical pregnancy after the IVF-ET in order to identify the factors related to the biochemical pregnancy. Methods Clinical data on 55 cycles of biochemical pregnancies and 100 cycles of clinical pregnancies were analyzed retrospectively. Step-wise logistic regression analysis was done to compare exposed influence factors between the two groups. Results Male age, primary or secondary infertility, use of gonadotropin-releasing hormone agonist in assisted reproduction cycles, ratio of fertilization, basic antral follicle count （AFC） and spontaneous abortion were the significant influence factors for biochemical pregnancies （P 〈 0. 05 ） . Furthermore, it was found that the basic AFC and the history of spontaneous abortion were the independent factors for biochemical pregnancy. Conclusion The occurrence of biochemical pregnancy in the IVF-ET treatment is affected by the age, ovarian reserve, ovarian hyperstimulation program and history of spontaneous abortion etc.
出处
《医学分子生物学杂志》
CAS
2014年第6期311-317,共7页
Journal of Medical Molecular Biology
基金
国家自然科学基金（No.81101971,81471508,81401276）
关键词
体外受精-胚胎移植
生化妊娠
危险因素
LOGISTIC回归
in vitro fertilization and embryo transfer
biochemical pregnancy
influential factor
logistic regression
