摘要
目的:系统评价谷氨酰胺(Gln)对腹部手术后病人肠黏膜通透性的影响。方法:通过计算机检索中国学术期刊全文数据库(CNKI)、中国生物医学文献数据库(CBMdisc)、万方数据库和Pub Med数据库等的文献资料,评价纳入随机对照研究,应用Rev Man 5.2软件进行Meta分析。结果:经筛选共纳入9篇病例对照研究,累计421例受试者。结果显示,Gln可以降低腹部手术后病人肠黏膜乳果糖/甘露醇的比值[WMD=-0.05,95%CI(-0.09,-0.01)(P=0.01)],降低腹部手术后病人二胺氧化酶浓度[WMD=-1.60,95%CI(-1.89,-1.31)(P<0.01)],并有降低术后病人循环D-乳酸的趋势,但无显著性差异[WMD=-8.14,95%CI(-18.12,-1.84)(P=0.11)]。结论:Gln能有效地降低外科腹部手术病人术后肠黏膜通透性,降低二胺氧化酶浓度,目前证据不能充分肯定Gln对循环D-乳酸有影响。
Objective ： To evaluate the influence of glutamine on the function of intestinal mucosa in patients with abdominal surgery. Methods： The following electronic databases were retrieved via computer system： EMBASE, Chinese CNKI , WanFang database and PubMed. The found randomized control trials were then appraised, and Meta analysis was conducted with RevMan 5.2. Results： After the screening,9 case-control studies were included. Results showed that the glutamine could decrease the ratio of lactulose and mannitol after abdominal surgery patients [ WMD = - 0.05,95% CI （ - 0.09, - 0.01 ） （ P = 0.01 ） ] and diamine oxidase concentration [ WMD = - 1.60,95 % CI （ - 1.89, - 1.31 ） （ P 〈 0. 01 ） ]. Conclusion ： Glutamine can effectively reduce the postoperative intestinal mucosal permeability and the concentration of diamine oxidase.
出处
《肠外与肠内营养》
CAS
北大核心
2014年第6期324-328,332,共6页
Parenteral & Enteral Nutrition
基金
国家"十二五"科技支撑计划课题(2012BAI35B03)
关键词
谷氨酰胺
腹部术后
肠黏膜屏障功能
系统评价
Glutamine
Abdominal operation
Intestinal barrier function
Systematicreview
