摘要
在晚期结直肠癌的疗效评价中,总生存期(overall survival)、无进展生存期(progression free survival)及基于实体瘤的疗效评价、生活质量及药物不良反应等疗效评价标准在临床中已得到了广泛的运用,但是在临床使用中其各自的疗效评定价值及意义却各不相同.同时,随着分子靶向药物及新的治疗方法的开展,现有疗效评价标准的缺点也不断的显露出来.因此,探索能够早期有效反映药物及治疗方法有效性的疗效评定指标成为必然.
Evaluation criteria like overall survival（OS）, progression-free survival（PFS）, the response evaluation criteria in solid tumors, quality of life and adverse reactions have been widely used in clinical studies of advanced colorectal cancer. However, these criteria have different significance, and with the development of molecular targeted drugs and new therapies, the drawbacks of these criteria have been revealed. Therefore, searching for new evaluation criteria which can reflect the curative effect in the earlier stage is becoming inevitable.
出处
《世界华人消化杂志》
CAS
北大核心
2014年第28期4281-4287,共7页
World Chinese Journal of Digestology
关键词
结直肠癌
疗效评价
分子靶向药物
Colorectal cancer
Evaluation criteria
Molecular targeted drugs
