摘要
目的探讨小儿重症肺炎并发心肌损害中心肌钙蛋白I(cardiac troponinⅠ,cTnⅠ)的测定及其意义。方法选取重症肺炎患儿200例为观察组,轻症肺炎患儿180例为轻症组,正常儿童200例为对照组,对比3组儿童cTnⅠ水平、肌酸激酶同工酶(creatine kinase MB,CK-MB)水平。结果观察组cTnI、CK-MB、肌酸激酶(creatine kinase,CK)、乳酸脱氢酶(lactate dehydrogenase,LDH)及天冬氨酸转氨酶(aspartate amino-transferase,AST)水平高于轻症组(P<0.05),观察组和轻症组cTnI、CK-MB、LDH、AST水平高于对照组(P<0.05)。观察组cTnI阳性率高于轻症组(P<0.05)。观察组与轻症组CK-MB阳性率差异无统计学意义(P>0.05)。结论重症肺炎患儿多伴有不同程度的心肌损害,cTnI可作为监测心肌损伤的重要标志物。早期检测cTnI有利于重症肺炎并发心急损害患儿的早期诊疗,从而预防心肌衰竭发生。
Objective To investigate the value of cardiac troponin I （CTnI）in children of severe pneumonia with myocardial damage.Methods A total of 200 children with severe pneumonia in our hospital were collected as observation group,180 children with mild pneumonia in our hospital in the same period were collected as mild group,200 cases of healthy children in the same period were collected as control group,CTnI level,creatine kinase MB（CK-MB）level of three groups were analyzed and compared.Results The cTnI,CK-MB,creatine Kinase （CK）, lactate dehydrogenase（LDH）and aspartate amino-transferase,AST（AST）levels of observation group were significantly higher than those of mild group （P〈0.05）,and cTnI positive rate of observation group was significantly higher than that of mild group （P〈0.05）.The difference of CK-MB level between the two groups was not significant（P〉0.05）.Conclusion Most children of severe pneumonia are associated with varying degrees of myocardial damage,cTnI can be used to monitor the condition of the children as an important marker of myocardial inj ury.Early detection of cTnI is favorable to the early diagnosis and treatment of severe pneumonia with myocardial damage,thereby preventing the occurrence of cardiac failure in the children.
出处
《河北医科大学学报》
CAS
2014年第10期1144-1147,共4页
Journal of Hebei Medical University
关键词
肺炎
肌酸激酶
儿童
肌钙蛋白 I
pneumonia
troponin I
creatine kinase
children
