摘要
目的 采用Meta分析方法了解我国大陆地区中草药致药物性肝损伤的发生率.方法 系统检索万方数据库（Wanfangdata）、中国期刊全文数据库（CNKI）、维普中文科技期刊全文数据库和中国生物医学文献数据库中1994年1月至2014年4月有关药物性肝损伤的回顾性研究,用R软件对中草药致药物性肝损伤药物发生率进行Meta分析,对数据进行异质性检验,以确定采用固定模型或随机模型进行率的合并分析,采用敏感性分析评价研究文献质量对结果的影响,并进行发表偏倚检测.结果 纳入68篇文献,总样本量为7647人,加权合并显示,中草药致药物性肝损伤发生率30.21％ （95％CI：26.76％～33.65％）,其中北方与南方地区无显著性差异（P＞0.05）.结论 中草药致药物性肝损伤发生率较高,应加强临床用药监测.
Objective： To understand the rate of drug-induced liver injury by Chinese herbal medicines in the mainland of China. Methods： Based on the related literature regarding the drug-induced liver injury in China National Knowledge Infrastructure Databases （CNKI）,Wangfang Databases,the Chinese Science and Technology Journal Databases （VIP）,Chinese Biomedical Literature Databases （CBM） from 1994 to 2014,the rates of druginduced liver injury by Chinese herbal medicines were analyzed in R software. Meanwhile, the fixed effects model or random effects model were employed according to the statistical tests for heterogeneity. Also ,the sensitivity analysis was performed to evaluate the impact of the quality. Results： 68 papers were included for Meta-analysis with a total sample of 7647.The combined prevalence rates of drug-induced liver injury by Chinese herbal medicines was 30.21%（95% CI： 26.76%-33.65%）. No significant differences were between northern and southern regions （P〉 0.05）. Conclusion： The rates of drug-induced liver injury by the Chinese herbal medicines is higer. The clinical medication monitoring should be enhanced.
出处
《中国中医急症》
2014年第11期1988-1989,2043,共3页
Journal of Emergency in Traditional Chinese Medicine
基金
北京市科委课题首都特色临床医学课题(Z090507017709030)
关键词
药物性肝损伤
META分析
中草药
Drug-induced liver injury
Meta analysis
Chinese herbal medicines
