摘要
哮喘是一种慢性气道炎症性疾病.检测、评估气道炎症对于哮喘的早期诊断、病情严重程度的判断、药物种类和剂量的选择以及对已控制症状患者停药时机的选择等,均有重要的临床指导意义,故迫切需要能客观地反映气道炎症的检测技术来指导哮喘的诊断和治疗.目前研究较多的炎症标志物主要有呼出气一氧化氮、白三烯、呼出气冷凝液测定、骨膜蛋白、人软骨糖蛋白等.该文就上述炎症标志物的生物学特性及在哮喘临床中的应用进行阐述.
Asthma is a chronic airway inflammatory disease.Detection and evaluation of airway inflammation has important clinical significance in asthma diagnosis and severity judgement.It is also important to select drugs,dosage,and withdrawal time for patients whose symptoms have been controlled.So,it is necessary to find the technology which can response to airway inflammation to guide the asthma diagnosis and therapy.At present,many inflammatory biomarkers have been researched including exhaled nitric oxide,leukotrienes,exhaled breath condensate determination,Periosrin,YKL-40 etc.This review summarizes the biological characteristics and clinical application of inflammatory markers in asthma.
出处
《国际儿科学杂志》
2014年第6期632-635,共4页
International Journal of Pediatrics
基金
南京医科大学科技发展基金面上项目(2013NJMU175)
关键词
哮喘
炎症
标志物
Asthma
Inflammation
Biomarker