摘要
目的：探讨血脂康对糖尿病小鼠氧化应激的影响。方法取6～8周龄的 BALB／c 雄性小鼠腹腔注射链脲佐菌素建立糖尿病模型，建模成功后随机分为非治疗组（5％阿拉伯胶，n＝6）和血脂康组（200 mg·kg^-1·d^-1，n＝6），腹腔注射相应药物，1次·d^－1，连续4周；另设正常对照组（n＝6）进行比较，检测各组小鼠建模成功后血糖水平及给药前，给药4周后尿液中8-异前列腺素（8-isoprostane）浓度。结果与正常对照组比较，非治疗组和血脂康组血糖值均明显升高（P ＜0．001），但2组间比较差异无统计学意义（P ＞0．05）；给药4周后，与正常对照组比较，非治疗组尿液中8-isoprostane 浓度明显升高（P ＜0．05），但血脂康组与正常对照组比较差异无统计学意义（P ＞0．05）。结论糖尿病小鼠体内氧化应激有所增强，血脂康具有一定抗氧化应激作用。
Objective To study the effect of Xuezhikang on oxidative stress of diabetic mice. Methods A diabetic model was established in 6-8-week-old male BALB/c mice by intraperitoneal injection of streptozotocin.Then,diabetic mice were intraperitoneally injected with either 5%Ara-bic gum（non-therapy group,n=6）or Xuezhikang 200 mg·kg^-1 ·d^-1 （Xuezhikang group,n=6） once per day for 4 weeks.In addition,health mice were selected as the normal control group（n=6）.The levels of blood glucose were detected after successful modeling and urinary concentrations of 8-isoprostane were determined before and after treatment for 4 weeks.Results Compared with normal control group,the levels of blood glucose were significantly increased in both non-therapy group and Xuezhikang group（P 〈0.001）,and urinary concentrations of 8-isoprostane were obvi-ously elevated in non-therapy group after treatment for 4 weeks（P 〈0.05）.However,there were no significant differences in blood glucose levels between non-therapy group and Xuezhikang group,as well as in urinary 8-isoprostane concentrations between Xuezhikang group and normal control group（P 〉 0.05）.Conclusion Diabetes mellitus leads to increased oxidative stress in mice and Xuezhikang reduces oxidative stress in diabetic mice.
出处
《南昌大学学报（医学版）》
CAS
2014年第9期19-21,共3页
Journal of Nanchang University：Medical Sciences
关键词
糖尿病
血脂康
氧化应激
8-异前列腺素
动物
实验
小鼠
diabetes mellitus
Xuezhikang
oxidative stress
8-isoprostane
animals, laboratory~ mice
