摘要
目的观察血小板去除术联合羟基脲,α-2 b干扰素及抗血小板药物治疗原发性血小板增多症(ET)的疗效。并评价血栓弹力图检测在血小板增多症中的应用价值。方法采用COBE SPECTRA和MCS+两种血细胞分离机对31例患者行血小板去除术,同时联合羟基脲,干扰素及常规抗血小板药物治疗。并应用血栓弹力图(TEG)监测患者去除治疗前后的凝血功能指标。结果 1血小板去除治疗后患者外周血中血小板计数明显下降,联合使用羟基脲/α-2b干扰素及抗血小板药物治疗,使病情得到较快和稳定的控制。2血小板去除治疗后,患者TEG检测结果显示血小板功能指标MA值明显降低,综合凝血指数CI值明显改善,R值,Angle角没有明显改变。3血小板的功能指标MA值与血小板计数之间没有明显相关性。结论血小板去除治疗联合羟基脲/干扰素及抗血小板药物治疗原发性血小板增多症疗效显著,血栓弹力图监测ET患者的凝血功能对指导治疗有重要意义。
Objective This retrospective study aims to assess the efficacy of the clinical effcet of therapeutic platelet reducion plus Hydroxyurea and IFNα-2b on essential thrombocythemia （ET）and evaluate the thrombelastography（TEG） system on ET.Methods 31 patients were treated with Hydroxyurea and IFNα-2b after therapeutic platelet reducion.TEG parameters were measured serially before and after therapeutic platelet reducion.Excel was used for data entry and SPSS 17.0 for data analysis.Results ①The platelet count of peripheral blood decreased significantly after therapeutic platelet reducion plus Hydroxyurea and IFNα-2b treated.②The TEG assays showed that clot strength （MA,maximal amplitude）significantly decreased and coagulation index（CI） was significantly improved.However,R time and angle were not changed significantly.③No significant correlation between PLT count increments and MA.Conclusion This study demonstrates that therapeutic platelet reducion plus Hydroxyurea and IFNα-2b treated significantly effect on ET.The TEG assay may prove useful in guiding treatment decisions on ET.
出处
《血栓与止血学》
2014年第6期319-321,共3页
Chinese Journal of Thrombosis and Hemostasis
关键词
血小板增多
血小板去除治疗
血栓弹力图
Essential thrombocythaemia
Therapeutic platelet reducion
Thrombelastography
