摘要
目的对更年期女性冠心病患者的心血管危险因素进行研究并就其干预现状进行调查。方法纳入某社区2011年5月的更年期女性500例,经心电图及冠脉造影检查对冠心病进行筛选,确诊冠心病患者162例为冠心病组,对冠心病组患者进行危险因素研究,并计算更年期女性冠心病的发病率;未患冠心病的更年期女性为非冠心病组,对其进行危险因素干预,随访3年后对非冠心病组患者新发病率进行总结,并对比冠心病组新发病率,判定干预效果。结果实验数据表明,更年期女性冠心病患者心血管危险因素有BMI(OR=1.499,P=0.032<0.05)、高密度脂蛋白胆固醇(OR=0.012,P=0.026<0.05)、低密度脂蛋白胆固醇(OR=13.251,P=0.016<0.05)、尿酸(OR=1.021,P=0.009<0.01)、高血压(OR=6.132,P=0.0075<0.01)、糖尿病(OR=8.124,P=0.0082<0.01)。对危险因素进行干预后,非冠心病组随访结果显示其新发病率(13.9%)明显低于原发病率(32.4%),对比差异显著(P=0.001<0.01),具有统计学意义。结论更年期女性冠心病患者心血管危险因素的研究及预防具有重要的临床作用和价值。
Objective Menopausal women with coronary heart disease risk factors of cardiovascular disease in the study and investigation of risk factors of intervention.Methods Into a community in May 2011 in menopausal women 500 cases,detected by ECG and coronary CT screening for coronary heart disease,162 patients diagnosed with coronary heart disease is coronary heart disease,coronary heart disease patients for risk factors and calculate the menopause the incidence of coronary heart disease women ; does not suffer from coronary heart disease in non-menopausal women with coronary heart disease risk factors in the intervention group were followed up for 3 years after the incidence of new patients with non-CAD group to summarize and compare the incidence of CHD new determine intervention.Results The experimental data show that cardiovascular risk in patients with coronary heart disease,menopausal women factors are BMI（OR =1.499,P =0.032 〈0.05）,high density lipoprotein cholesterol（OR =0.012,P =0.026 〈0.05）,low density lipoprotein cholesterol（OR =13.251,P =0.016 〈 0.05）,uric acid （OR =1.021,P =0.009 〈 0.01）,hypertension （OR =6.132,P =0.0075 〈 0.01）,diabetes mellitus（OR =8.124,P =0.0082 〈 0.01）.After the intervention of the risk factors for non-CHD group follow-up results show its new incidence（13.9%）was significantly lower than the original incidence （32.4 %）,compared significant difference （P =0.001 〈 0.01）,with statistical significance.Conclusion Has an important clinical role and value of research and prevention of Mcoronary heart disease in menopausal women with cardiovascular risk factors.
出处
《血栓与止血学》
2014年第6期289-292,共4页
Chinese Journal of Thrombosis and Hemostasis
关键词
冠心病
更年期女性
危险因素
干预现状
Coronary heart disease
Menopausal women
Risk factors
Intervention status
