摘要
目的应用ROC曲线确定ELISA法检测泡型包虫病的诊断界值。方法筛选经金标准确认的34例泡型包虫病标本,通过ELISA法检测,通过ROC曲线分析确定诊断界值,并根据其诊断界值计算诊断敏感度和特异度。结果当诊断界值为0.44时,ROC曲线下面积最大,为0.995,诊断敏感度为97.06%,特异度为97.06%。结论 ROC曲线法是寻找ELISA法诊断界值的最佳方法。
Objective To determine the ELISA cut-off value for the diagnosis of alveolar echinococcosis by applying ROC curve.Methods 34 cases of alveolar echinococcosis specimens confirmed by the gold standard were selected and detected by ELISA.The diagnostic cut-off value was determined by ROC curve,and the sensitivity and specificity were calculated according to the cut-off value.Results When the cut-off value was 0.44,the ROC curve had the largest area under the curve(AUC)accounting of 0.995,and the sensitivity and specificity were 97.06%and 97.06%respectively.Conclusion The ROC curve is the best way to determine the cut-off value of ELISA.
出处
《国际检验医学杂志》
CAS
2014年第22期3090-3091,共2页
International Journal of Laboratory Medicine
基金
新疆包虫病基础医学重点实验室开放课题基金资助(XJDX0202-2011-08)
关键词
ROC曲线
酶联免疫吸附测定
泡型包虫病
诊断界值
ROC curve
enzyme linked immunosorbent assay
alveolar echinococcosis
cut-off value