摘要
目的探讨膝骨关节炎(KOA)患者血清脂联素水平与KOA严重程度的相关性。方法选取KOA患者179例,用骨关节炎指数(WOMAC)评分方法系统评估其关节炎症状严重程度;用Kellgren-Lawrence(KL)分级方法对KOA患者双膝关节放射学严重程度进行评估,选取较严重一侧膝关节纳入研究;使用酶联免疫吸附法(ELISA)测定患者血清脂联素水平。结果 1男女血清脂联素水平差异无统计学意义(Z=-1.417,P=0.157)。2血清中脂联素水平与病程(rs=-0.156,P<0.05)、KL分级(rs=-0.235,P<0.01)及载脂蛋白A(rs=-0.323,P=0.001)存在负相关性;与WOMAC总分、WOMAC疼痛、WOMAC僵硬、WOMAC功能障碍、体重指数、血糖等均无相关性(P>0.05)。3血清脂联素水平与X线KL分级呈负相关性(rs=-0.235,P<0.01)血清脂联素水平在各KL分级中分布差异有统计学意义(χ2=10.656,P<0.01)。4以脂联素作为应变量进行多元线性回归分析显示:KL分级与脂联素及腰臀比之间差异有统计学意义(β=-6 259.967,P=0.008;β=79 165.563,P=0.047)。结论血清脂联素水平与KOA患者关节症状严重程度无关,与关节放射学严重程度相关,提示脂联素可能对关节软骨起到保护作用。
Objective To measure adiponectin concentrations in plasma of patients with knee osteoarthritis（KOA） and to investigate the correlation of adiponectin levels with disease severity.Methods 179 OA patients were enrolled in this study.The severity of symptoms was assessed with The Western Ontario and McMaster Universities osteoarthritis index （WOMAC）scoring system;the Kellgren-Lawrence （KL）criteria were adopted to evaluate X-ray changes observed in anteroposterior knee radiography;adiponectin levels in plasma and synovial fluid were determined by enzyme-linked immunosorbent assay （ELISA）.Results ① There was no significant difference （Z =-1.417,P =0.157） between male and female of the serum adiponectin.② Adiponectin concentrations in plasma showed significant inverse correlation with disease duration（rs =-0.156,P ＜0.05）,KL grade（rs =-0.235,P ＜ 0.01） and apolipoprotein A（rs =-0.323,P =0.001）.There was no correlation between adiponectin and total WOMAC scores,pain scores,stiffness scores,dysfunction scores,body mass index and fasting blood-glucose （P ＞ 0.05）.③ The differences of serum adiponectin level in the KL grades distribution had statistical significance（x2 =10.656,P ＜0.01）.④ Additionally,linear regression analysis showed that adiponectin and KL classification and WHR had statistical significance （β =-6 259.967,P =0.008;β =79 165.563,P =0.047,respectively）.Conclusion In this pilot study,we find that adiponectin serum concentrations are not associated with knee osteoarthritis symptom severity.However,adiponectin serum concentrations are associated with knee osteoarthritis radiographic severity.These findings suggest that adiponectin may protect the articular cartilage and play a protective role in OA.
出处
《安徽医科大学学报》
CAS
北大核心
2014年第12期1792-1795,共4页
Acta Universitatis Medicinalis Anhui
基金
国家自然科学基金(编号:81172865)
