摘要
目的了解以经导管动脉化疗栓塞(TACE)为基础联合全身化疗、分子靶向治疗、门静脉栓塞、射频消融等多种治疗方案对不可切除的结直肠癌肝转移患者进行治疗的新进展,探索适用于晚期结直肠癌肝转移患者安全、有效的联合治疗方法,从而控制疾病快速进展,改善患者生存质量。方法收集国内外有关以TACE为主导的联合治疗方案应用于结直肠癌肝转移外科治疗新进展的文献,就联合方案应用于结直肠癌肝转移治疗的新进展以及各联合治疗方案的优势与特点进行综述。结果对于晚期原发或继发性肝脏恶性肿瘤,TACE是一种安全、有效的治疗方法,在此基础上联合其他治疗方案与单一的治疗方案相比,在提高患者生活质量、延长生存时间这两方面均具有明显优势。随着各种新的治疗药物的不断涌现,多种介入治疗方式的快速发展,都为改善结直肠癌肝转移患者的远期生存带来利好因素。结论我们应该加强对不可手术切除的结直肠癌肝转移综合治疗的重视,提高对晚期肿瘤个体化治疗的认识,积极推动联合治疗方案在结直肠癌肝转移治疗中的应用。
Objective To understand the latest progress of transcatheter arterial chemoembolization （TACE） - based combination therapies for unresectable liver metastasis from colorectal carcinoma, and to explore the safe and effective combination therapies in order to controlling the rapid progress of disease and improving the quality of life of patients. Methods The literatures about TACE-based combination therapies of liver metastasis from colorectal carcinoma and the latest advance in researches of this field at home and abroad were collected, and the application of combination therapies, the advantages and features of the combined treatments were reviewed. Results TACE was a safe and effective therapeutic modality in treating primary liver cancer or secondary liver cancer. Compared with a single treatment, TACE-based combination therapies had distinct advantages to patients with liver metastasis from colorectal carcinoma not only improved the quality of life but also prolonged the survival time. With the emerging of various kinds of new drugs and the rapid development of a variety of interventional treatments, it could bring long-term survival benifit for patients with liver metastasis from colorectal carcinoma. Conclusions Doctors should pay attention to the combined treatments of patients with liver metastasis from colorectal carcinoma, improve the knowledge of personalized medication about advanced tumors and actively promote more usage of combination therapies.
出处
《中国普外基础与临床杂志》
CAS
2014年第11期1360-1365,共6页
Chinese Journal of Bases and Clinics In General Surgery
关键词
结直肠癌肝转移
经导管动脉化疗栓塞
全身化疗
分子靶向治疗
门静脉栓塞
射频消融
Liver metastasis from colorectal carcinoma
Transcatheter arterial chemoembolization
Systemicchemotherapy
Molecular targeted therapy
Portal vein embolization
Radiofrequency ablation
