摘要
目的应用二联血清法与滤纸干血片法对孕中期Down’s综合征进行产前筛查,以了解其一致性。方法应用DELFIA法同时应用PE公司产前筛查血清二联法及滤纸干血片法分析AFP及Freeβ-HCG含量。结果血清与血片法以血清法为金标准,DS切值均为1/270时,其敏感度为93.22%,特异度为99.8%,准确度为99.5%。结论经筛查1479例中孕妇女血清法筛查高风险率3.99%(59/1479),滤纸干血片法高风险率为3.92%(58/1479),P>0.05,χ2=0.01,无统计学差异,显示产筛二联血清法与滤纸干血片法对于DS筛查高风险者结果一致性好,可推广应用于中孕期DS筛查。
Objective：Duplex serum method and dried blood specimen method was applicated to screen Down＇s syndrome in mid pregnancy women,in order to understand the consistency of this two methods. Methods：Duplex serum method and dried blood specimen method（PE company）combined with DELFIA method to analysis the levels of AFP and Freeβ-HCG in mid pregnancy women. Results：Serum method as the gold standard,when DS value was 1/270,its sensitivity was 93.22%,the specificity was 99.8%,the accuracy is 99.5%. Conclusions：Screening in 1479 cases of pregnant women,high-risk rate was 3.99%（59/1479）in duplex serum method,3.92%（58/1479）in dried blood specimen method,P〉0.05,χ^2=0.01,the two methods were not significant difference by statistics analysis.The results show that duplex serum method and dried blood specimen method had good consistency,can be applied in screening Down s syndrome in mid pregnancy women.
出处
《中国优生与遗传杂志》
2014年第11期80-81,F0003,共3页
Chinese Journal of Birth Health & Heredity
