摘要
目的观察别嘌呤醇在急性心肌梗死合并高尿酸血症患者中的疗效。方法选取2011年11月至2013年6月在青岛市中心医院心内科治疗的急性心肌梗死合并高尿酸血症患者75例,使用随机数字表分为对照组(37例)和治疗组(38例)。对照组给予抗血小板、抗凝以及降脂治疗,治疗组在对照组的基础上加用别嘌呤醇。检测血清N端脑钠肽前体(NT-proBNP)水平变化,确诊急性心肌梗死6个月后进行6分钟步行试验。结果治疗1周后,与治疗前比较,对照组和治疗组NT-proBNP水平均明显下降(P均<0.01)。治疗1周后,与对照组[(396±264)pg/ml]比较,治疗组[(256±215)pg/ml]NT-proBNP水平下降(P<0.05)。6分钟步行试验(6MWT)结果显示,对照组为(263±70)m,治疗组为(337±62)m。治疗组明显高于对照组,两组差别具有显著统计学意义(P<0.01)。结论在急性心肌梗死合并高尿酸血症患者中应用别嘌呤醇治疗可以降低NT-proBNP水平,增加6MWT距离,改善心功能。
Objective To observe the curative effect of allopurinol in patients with acute myocardial infarction （AMI） complicating hyperuricemia. Methods The patients （n=75） were chosen from Nov. 2011 to Jun. 2013, and divided into control group （n=37） and treatment group （n=38） by using random number table. The control group was given anti-platelet, anti-thrombosis and lowing-lipid therapy, and treatment group was given allopurinol besides of the same therapy in control group. The changes of serum N-terminal pro brain natriuretic peptide （NT-proBNP） were detected, and 6-minute walk test （6MWT） was given to patients after diagnosis of AMI for 6 m. Results After treatment for 1 w, the level of NT-proBNP decreased significantly in control group and treatment group （all P〈0.01）. The level of NT-proBNP decreased in treatment group [（256±215） pg/mL] compared with control group [（396± 264） pg/mL, P〈0.05] after treatment. 6MWT was （263±70） min in control group and （337±62） m in treatment group （P〈0.01）. Conclusion Allopurinol can reduce the level of NT-proBNP, increase 6MWT and improve heart function in patients with AMI complicating hyperuricemia.
出处
《中国循证心血管医学杂志》
2014年第4期436-437,441,共3页
Chinese Journal of Evidence-Based Cardiovascular Medicine
关键词
别嘌呤醇
心肌梗死
高尿酸血症
B型利钠肽
Allopurinol
Myocardial infarction
Hyperuricemia
B-type natriuretic peptide
