摘要
利用紫外吸收光谱法、等温滴定量热法、1H NMR法等研究了麦穗宁与瓜环Q[n](n=6,7,8)的超分子相互作用,讨论了瓜环/麦穗宁超分子体系的形成对麦穗宁的pKa及抑菌活性的影响.实验结果表明,麦穗宁与Q[n](n=6,7,8)均形成1∶1的主客体配合物,瓜环/麦穗宁超分子体系的形成使麦穗宁的pKa发生了明显移动,且对麦穗宁有助溶作用;Q[6]、Q[7]的加入减弱了麦穗宁对小麦赤霉的抑菌活性,而Q[8]的加入则增强了麦穗宁对小麦赤霉的抑菌活性.
Interaction between cucurbit[n]uril （Q[n], n=6, 7, 8） and fuberidazole （FBZ） in HCl solution at pH 2.5 was inves-tigated by UV-Vis spectroscopy, ITC, 1H NMR spectroscopy. The shift of pKa and bioactivities against Fusarium graminearum about fuberidazole and its host-guest inclusion complexes were discussed. The results showed that the inclusion complexes between cucurbit[n]urils and fuberidazole were formed, and the corresponding pKa of complexes have shifted. In addition, complexation by Q[n] （n=6, 7, 8） has proven to cause solubility enhancement. The activity experimental results showed that complexation of fuberidazole with Q[n] （n=6, 7） recedes activity against Fusarium graminearum while with Q[8] enhances the activity against Fusarium graminearum in vivo.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2014年第11期2317-2323,共7页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.21202026)
教育部春晖计划(No.Z2011034)
贵州省科技厅国际合作(No.黔科合外G字[2012]7003号)
贵州省英才培育(No.2012154)资助项目~~
