摘要
目的 探讨无创呼吸机治疗对慢性阻塞性肺疾病急性加重期（AECOPD）合并肝损害的疗效,并调查其医疗费用.方法 将合并有肝损害的AECOPD患者112例随机分为两组,治疗组72例接受无创呼吸机治疗,对照组40例未接受无创呼吸机治疗.两组患者均常规给予抗感染、平喘、祛痰、护肝、纠正水电解质及酸碱失衡、雾化吸入及氧疗等对症支持治疗,观察两组的临床疗效,并比较两组患者住院天数、住院费用及住院病死率.结果 治疗组肝功能、血PaO2、PaCO2比对照组改善明显（P＜0.05）;治疗组、对照组住院天数分别为（10.2±5.0）天和（14.1±6.0）天,病死率分别为8.3％和12.5％,治疗组均低于对照组（P＜0.05）;治疗组、对照组平均住院费用分别为（7 143±325）元和（8 213±401）元,两组间比较差异无统计学意义（P＞0.05）.结论 对慢性阻塞性肺疾病急性加重期合并肝损害患者早期行无创通气,可以改善患者病情和预后,且并不增加患者经济负担.
Objective To investigate the efficacy of noninvasive ventilation in the treatment period with liver damage on acute exacerbation of chronic obstructive pulmonary disease （ AECOPD）, and to investigate their medical expenses. Methods 112 cases of chronic obstructive pulmonary disease with clinical data of patients with liver damage were divided into two groups ： receiving noninvasive ventilator in treatment of 72 cases of the treatment group. 40 patients did not receive noninvasive ventilation in the treatment of patients in the control group. Two groups of patients were given conventional anti-infection, asthma, expectorant, anti-inflammatory, hepatoprotective, correcting water electrolyte and acid-base imbalance, atomization inhalation and oxygen therapy treatment, comparison of two groups of clinical curative effects, and statistical in-hospital mortality, hospitalization expenses and hospitalization days of patients in two groups. Results The treatment group,liver function, blood PO2 , PCO2 than in the control group improved significantly （P 〈 0.05 ）. Treatment group and control group hospitalization days, respectively（ 10.2 ± 5.0） and （14.1± 6.0） days, mortality rates were 8.3% and 12.5 % respectively, the treatment group were lower than the control group（ P 〈 0.05 ）. The average hospitalization expenses in treatment group and control group respectively（7 143 ± 325 ）yuan and（ 8 213 ±401 ）yuan, comparison between the two groups had no significant difference （ P 〉 0. 05 ）. Conclusion The effect of noninvasive ventilation in the treatment of the acute exacerbation of chronic obstructive pulmonary disease patients with early stage of liver injury, can improve the patients condition and prognosis, and does not increase the economic burden of the patients.
出处
《临床内科杂志》
CAS
2014年第9期601-603,共3页
Journal of Clinical Internal Medicine
