摘要
目的:了解我院近10年药物性肝损害(DILI)相关不良反应(ADR)的发生情况及规律,为临床合理用药提供参考。方法:对我院2003-2012年DILI相关ADR报告筛选后,从患者性别、年龄、过敏史、药品品种、给药途径、ADR发生的时间、ADR性质、临床表现及严重ADR等多个方面进行分析。结果:我院药物性肝损害ADR在≥50岁的中老年人中发生居多(占75.23%);引发DILI的药品种类以抗微生物药和循环系统药为主,92.66%为潜伏性,丙氨酸转氨酶(ALT)升高倍数<5倍正常上限值(ULN)例数占77.06%;17.43%有临床表现,症状多较轻微;23.85%痊愈,74.31%好转。结论:DILI发生特点多为潜伏性,临床表现多不明显或轻微,预后较好。医药工作者应积极开展DILI预防和控制工作,以更好地保障患者用药安全。
OBJECTIVE： To analyze feature and regularity of drug-induced liver injury （DILI） related adverse drug reactions （ADR） reports in our hospital in recent l0 years, and to provide reference for clinical rational drug use. METHODS： DILl related ADR cases in our hospital from 2003 to 2012 were selected and analyzed in respects of patient＇s gender and age, allergic history, drug type, dosage form, occurrence time of ADR, property, clinical manifestations, severe ADR. RESULTS： The incidence of ADR were higher in senile patients aged ≥50 years; the types of DILI-inducing drugs most were the circulatory system drugs and anti-microbial drugs; 92.66% of DILl was latent, the case number of ALT elevations multiples〈 5 （ULN） accounted for 77.06 % ; 17.43% had slight clinical manifestations; 23.85% were recovered and 74.31% were improved. CONCLUSIONS： DILl features in- clude mostly latent, slightly clinical manifestation and good prognosis. In order to better protect the safety of drug use, medical workers should actively conduct DILI prevention and control.
出处
《中国药房》
CAS
CSCD
2014年第46期4372-4376,共5页
China Pharmacy
基金
国家中医药管理局"十二五"重点专科项目(No.ZP0101YX001)
