摘要
目的：探讨肺炎克雷伯菌耐药性与抗菌药物使用量的相关性,为临床合理使用抗菌药物提供依据。方法：采用回顾性调查方法,分别统计我院2009-2013年9种抗菌药物用药频度（DDDs）和肺炎克雷伯菌的耐药率,采用SPSS 18.0版软件对肺炎克雷伯菌的耐药率和抗菌药物DDDs进行相关性分析。结果：肺炎克雷伯菌对庆大霉素的耐药率始终处于20.0%~30.0%,对哌拉西林/他唑巴坦、头孢他啶、头孢吡肟、环丙沙星、左氧氟沙星耐药率呈先降后升趋势,对亚胺培南的耐药率呈上升趋势（1.5%~25.5%）。哌拉西林/他唑巴坦DDDs与亚胺培南、环丙沙星耐药率呈高度相关（r=0.902、0.911）;氨曲南DDDs与亚胺培南、环丙沙星、左氧氟沙星耐药率呈高度负相关（r=-0.917、-0.896、-0.954）;亚胺培南DDDs与亚胺培南、环丙沙星、左氧氟沙星耐药率高度相关（r=0.970、0.990、0.950）;庆大霉素DDDs与亚胺培南、环丙沙星、左氧氟沙星耐药率呈高度负相关（r=-0.956、-0.896、-0.937）;环丙沙星DDDs与头孢吡肟、左氧氟沙星呈高度相关（r=0.900、-0.901）。其余抗菌药物DDDs与耐药率无相关性。结论：细菌耐药率与抗菌药物使用量存在相关性,提示临床应合理使用抗菌药物,减少或延缓耐药菌株的产生。
OBJECTIVE： To investigate the correlation of drug resistance to Klebsiella pneumoniae with the consumption of an- tibacterial drugs, so as to provide the evidence for rational use of antibacterial drugs. METHODS： Using retrospective method, DDDs of 9 kinds of antibacterial drugs and drug resistance to K. pneumoniae were analyzed statistically in our hospital during 2009- 2013. The correlation of drug resistance to K. pneumoniae with DDDs of 9 kinds of antibacterial drugs was analyzed using SPSS 18.0 software. RESULTS： The drug resistance to K. pneumoniae to gentamicin maintained 20.0%-30.0%; to piperacillin/tazo- bactam, ceftazidime, cefepine, ciprofloxacin and levofloxacin showed an upward trend firstly and downward trend at last; to imipe- nem showed an upward trend （1.5%-25.5%）. DDDs of piperacillin/tazobactam was closely correlated to drug resistance of imipen- em and ciprofloxacin （r= 0.902, 0.911 ）; DDDs of aztreonam was closely correlated to drug resistance of irnipenem, ciprofloxacin and levofloxacin （r = -- 0.917, -- 0.896, -- 0.954） ; DDDs of imipenem was closely correlated to drug resistance of imipenem, cipro- floxacin and levofloxacin （r=0.970,0.990,0.950）; DDDs of gentamicin was closely correlated to drug resistance of imipenem, cip- rofloxacin and levofloxacin （r=-0.956,- 0.896,- 0.937）; DDDs of ciprofloxacin was closely correlated to drug resistance of ce- fepine and levofloxacin （r=0.900,- 0.901）; DDDs of other antibacterial drugs were not correlated to drug resistance.
出处
《中国药房》
CAS
CSCD
2014年第46期4349-4352,共4页
China Pharmacy
关键词
肺炎克雷伯菌
耐药性
用药频度
相关性
There is a correlation between drug resistance of bacterial and the consumption of antibacterial drugs, which indicates that rational use of antibacterial drugs should be strengthened to reduce or delay the generation of drug-resistant strains. KEYWORDS Klebsiella pneumoniae
Drug resistance
DDDs
Correlation
