摘要
目的观察CT引导下靶位注射胶原酶治疗腰椎间盘突出症的临床效果。方法选择2011年1月至2013年1月收治的腰椎间盘突出症患者72例,其中男42例,女30例,年龄20~69岁。按照随机数字法分为两组,每组36例。观察组CT引导下靶位注射胶原酶治疗,对照组凭经验非CT引导注射胶原酶治疗。随访6个月,比较治疗前及治疗6个月后疼痛评分情况,并进行疗效评定。结果观察组穿刺一次成功31例（86.11%）,明显优于对照组（P〈0.05）;观察组疗效优27例（75.00%）,良6例（16.67%）,尚可2例（5.56%）,差1例（2.78%）,优良率达33例（91.67%）;对照组优良26例（72.22%）,差异明显（P〈0.05）;观察组治疗后疼痛视觉模拟（VAS）评分为（3.56±1.11）分,明显优于对照组的（6.54±1.16）分（P〈0.05）,且明显优于治疗前（7.98±1.35）分（P〈0.05）。结论 CT引导下靶位注射胶原酶治疗腰椎间盘突出症临床效果较佳,缓解疼痛显著,具有重要的临床价值。
Objective To observe the clinical effect of CT guiding targeted collagenase injection in the treatment of protrusion of lumbar intervertebral disc. Methods 72 cases of protrusion of lumbar intervertebral disc treated in our hospital from January 2011 to January2013 were selected as the research subjects and consistent with the diagnosis of protrusion of lumbar intervertebral disc, including 42 males and 30 females aged 20- 69 years old. They were randomly divided into two groups according to the random number table,36 cases in each group. The observation group adopted CT guiding targeted collagenase injection,while the control group took the collagenase injection by experience without CT guiding. The two groups were followed up for 6 months. Then the pain scores were compared between before treatment and after 6- month treatment. And the curative effect was evaluated. Results 31 cases（ 86. 11%） in the observation group were the once puncture success,which was significantly better than that in the control group（ P 0. 05）; in the observation group,the excellent effect was in 27 cases（ 75. 00%）,good effect in 6 cases（ 16. 67%）,fair effect in 2 cases（ 5. 56%） and poor effect in 1 case（ 2. 78%）,the excellent and good effects were achieved in 33 cases（ 91. 67%）; but in the control group,the excellent and good effects were in 26 cases（ 72. 22%）, the difference showed the statistical significance（ P 0. 05）; the observation group was significantly superior to the control group in the VAS scores after treatment [（ 3. 56 ± 1. 11） points vs.（ 6. 54 ± 1. 16） points, P 0. 05 ],moreover significantly superior to before treatment [（ 3. 56 ± 1. 11） points vs.（ 7. 98 ± 1. 35） points, P 0. 05 ]. Conclusion CT guiding targeted collagenase injection has good clinical effect in the treatment of protrusion of lumbar intervertebral disc,can relieve pain obviously and has important clinical value.
出处
《中国药业》
CAS
2014年第21期98-99,共2页
China Pharmaceuticals
关键词
CT引导
靶位注射
胶原酶治疗
腰椎间盘突出症
CT guiding
targeted injection
collagenase therapy
protrusion of lumbar intervertebral disc
