摘要
目的比较不同剂量阿托伐他汀钙对急性冠脉综合征(ACS)患者的血脂及高敏C反应蛋白(hs-CRP)的影响。方法将200例住院ACS患者随机分为A组(100例):每晚口服阿托伐他汀钙20mg,B组(100例):每晚口服阿托伐他汀钙40mg。比较服药前及服药后第4周、8周两组患者血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDLC))、hs-CRP水平及药物不良反应发生率。结果治疗4周后,两组患者血清TC、LDL-C及hs-CRP水平较治疗前均明显下降(均P<0.05),TG组间比较尚无显著差异,LDL-C及hs-CRP组间比较有差异。治疗8周后B组患者血清TC、LDL-C和hs-CRP的降低显著大于A组[(3.53±0.45)vs(4.07±0.54);(1.86±0.44)vs(2.25±0.45);(7.13±5.21)vs(12.48±5.72),均P<0.05)]。HDL-C两组均明显升高(均P<0.05),而B组升高显著大于A组[(1.65±0.45)vs(1.48±0.47),P<0.05)]。两组药物不良反应发生率无显著差异(P>0.05)。结论40mg较20mg阿托伐他汀钙,能进一步降低血清TC、LDL-C及hs-CRP水平,斑块稳定性可能更强,而安全性相当。
Objective To observe effects of Atovastatin Calcium （Ato） of higher dose on inflam-mation and blood lipid in patients with acute coronary syndrome （ACS） .Methods Two hundred pa-tients with ACS were randomly divided into two groups which were group A （Ato 20 mg/d） and group B （Ato 40 mg/d） .The treatment was lasted for 8 weeks .high-sensitivity c-reactive protein （hs-CRP） and blood lipid were tested and compared before and 4 ,8 weeks after treatment .Results Total choles-terol （TC） ,low -density lipoprotein cholesterol （LDL-C） and the hs-CRP levels were significantly lower （P〈0 .05） 4 weeks after treatment ,but there was no significant difference between TG groups A and groups B .8 weeks after treatment TC ,LDL-C and hs-CRP in group B was significantly lower than that in group A [（3 .53 ± 0 .45） vs （4 .07 ± 0 .54） ,（1 .86 ± 0 .44） vs （2 .25 ± 0 .45） ,（7 .13 ± 5 .21） vs （12 .48 ± 5 .72） ,（all P〈0 .05）] ,high density lipoprotein cholesterol （HDL-C） in the two groups was significantly higher （P〈0 .05） ,and was significantly higher in group B than in group A[（1 .65 ± 0 .45） vs （1 .48 ± 0 .47） ,P〈0 .05）] .Conclusion Effects of 40 mg/d Ato were better than 20 mg/d Ato on the patients with ACS .
出处
《贵州医药》
CAS
2014年第8期679-681,共3页
Guizhou Medical Journal
基金
贵州省国际科技合作计划项目(黔科合G字[2012]7047号)
关键词
急性冠脉综合征
阿托伐他汀钙
高敏C反应蛋白
血脂
Acute coronary syndrome
Atovastatin
Calcium high sensitivity c-reactive protein
Blood lipid
