摘要
目的:探讨大脑中动脉狭窄(MCAS)与轻度认知功能损障碍(MCI)的相关性及他汀类药物改善MCI的临床疗效。方法:连续选取在本院行经颅多普勒彩色超声(TCD)检查的住院或门诊患者636例,以简易精神状态检查量表(MMSE)和临床痴呆评定量表(CDR)作为认知功能评价指标,筛查MCI者158例,其中MCI并MCAS者44例及MCI不并MCAS者58例为治疗组,在常规及高血压、糖尿病等基础疾病治疗基础上,口服阿托伐他汀钙20 mg/d;选取MCI不并MCAS者56例为对照组,1年后复测MMSE评分。结果:124例MCAS患者中有MCI者44例,患病率为35.5%,512例非MCAS患者中为MCI者114例,患病率为22.3%,两组患病率比较差异有统计学意义。治疗后阿托伐他丁治疗组中MCI并MCAS患者及MCI不并MCAS患者的MMSE得分较治疗前有改善,差异有统计学意义,且MCAS合并MCI组改善更为明显。结论:MCAS与MCI的发生有关,阿托伐他汀钙能改善MCI患者近期记忆力,对合并MCAS引起的MCI患者疗效更显著。
Objective To investigate the correlation of the middle cerebral artery stenosis （MCAS） and the mild cognitive function impairment （MCI）, and the clinical efficacy of statins in patients with MCI. Methods Six hundred and thirty-six patientse, who received transcranial color doppler ultrasound （TCD）assay, were enrolled in our hospital hospitalization or outpatients. The simpte mental state examination （MMSE） and clinical dementia rating scale （CDR） were used as cognitive function assessment indexes. Forty-four cases of MCI with MCAS and 58 cases of MCI with NMCAS were used as the treatment group, who received the atorvastatin 20 mg every day, 56 cases of MCI with NMCAS were used as the control group, who only received the routine and basic diseases treatment. One yearlater,we determined the changes of MMSE and CDRagain. Results We detected 124 patients with MCAS, 512 patients with NMCAS, and 44 cases of MCAS patients with MCI, the prevalence was 35.5%, 114 cases of NMCAS in patients with MCI, with the prevalence of 22.3%, the prevalence between the two groups was statistically different. One year later, the patients in the treatment group, MMSE score was improved, the score of MCI of the MCAS group improved more significantly. Conclusion The middle cerebral artery stenosis correlated with the occurrence of MCI. Atorvastatin could improve cognitive function in patients with MC1, especially for MCI which was caused by middle cerebral artery stenosis.
出处
《实用医学杂志》
CAS
北大核心
2014年第22期3603-3605,共3页
The Journal of Practical Medicine
基金
广州市科技局计划项目(编号:20110511)
关键词
认知功能障碍
大脑中动脉狭窄
他汀药物
药效评价
Cognitive impairment
Middle cerebral artery stenosis
Statins
Efficacy evaluation
