摘要
目的 分析评价子宫富于细胞性平滑肌瘤中雌激素受体（ER）、孕激素受体（PR）、Ki-67的表达及临床意义.方法 收集2010～2014年湖北省妇幼保健院41例子宫富于细胞性平滑肌瘤、12例普通型子宫平滑肌瘤、5例恶性潜能未定子宫平滑肌瘤及10例子宫平滑肌肉瘤患者的子宫组织标本,采用免疫组化法检测各子宫组织中ER、PR以及Ki-67的表达水平.结果 ER在普通型子宫平滑肌瘤（83.3％）、富于细胞性平滑肌瘤（90.2％）以及恶性潜能未定型平滑肌瘤的阳性表达率（80.0％）逐渐下降,差异无统计学意义（P＞0.05）.ER在普通型子宫平滑肌瘤、富于细胞性平滑肌瘤以及恶性潜能未定型平滑肌瘤的阳性表达率均显著高于子宫平滑肌瘤肉瘤（10.0％）的表达,差异有高度统计学意义（P＜0.01）.PR在普通型子宫平滑肌瘤（100.0％）、富于细胞性平滑肌瘤（97.6％）以及恶性潜能未定型平滑肌瘤的阳性表达率（80.0％）逐渐下降,但差异无统计学意义（P＞0.05）.PR在普通型子宫平滑肌瘤、富于细胞性平滑肌瘤以及恶性潜能未定型平滑肌瘤的阳性表达率均显著高于子宫平滑肌瘤肉瘤（20.0％）,差异有高度统计学意义（P＜0.01）.Ki-67在普通型子宫平滑肌瘤[（0.020±0.009）个/10 HPF]、富于细胞性平滑肌瘤中[（0.039±0.011）个/10 HPF]的表达量比较,差异无统计学意义（P＞0.05）.Ki-67在普通型子宫平滑肌瘤、富于细胞性平滑肌瘤中的表达均显著低于恶性潜能未定型平滑肌瘤[（0.231±0.077）个/10 HPF]和子宫平滑肌肉瘤中[（0.320±0.103）个/10 HPF]的表达,差异有高度统计学意义（P＜0.01）.子宫富于细胞性平滑肌瘤组织中ER和PR表达没有明显的相关性（P＞0.05）,两者与Ki-67呈显著正相关（r=0.399、0.452,P＜0.05）.结论 子宫富于细胞性平滑肌瘤组织中ER和PR高表达,ER和PR的表达与Ki-67呈正相关.ER、PR和Ki-67的表
Objective To analyze clinical significance and expression of ER,PR and Ki-67 in cellular leiomyoma. Methods 41 tissue samples of cellular leiomyoma, 12 tissue samples of common type uterine leiomyoma, 5 tissue sam- ples of uncertain malignant potential of uterine leiomyoma, and I0 tissue samples of uterine leiomyosarcoma from 2010 to 2014 in Maternal and Child Health Hospital of Hubei Province were selected, and the expression of ER, PR and Ki- 67 in different uterus tissues were detected by immunohistochemical methods. Results The positive expression rate of ER in common type uterine leiomyoma （83.3%）, cellular leiomyoma （90.2%） and malignant potential undifferentiated leiomyoma （80.0%） showed downward trend, but there was no significant difference （P 〉 0.05）. The positive expression rate of ER in common type uterine leiomyoma, cellular leiomyoma and malignant potential undifferentiated leiomyoma were apparently higher than uterine fibroids sarcoma （10.0%）, the differences were statistically significant （P 〈 0.01）. The positive expression rate of PR in common type uterine leiomyoma （100.0%）, cellular leiomyoma （97.6%） and ma- lignant potential undifferentiated leiomyoma （80.0%） showed downward trend, but there was no significant difference （P 〉 0.05）. The positive expression rate of PR in common type uterine leiomyoma, cellular leiomyoma and malignant po- tential undifferentiated leiomyoma were apparently higher than uterine fibroids sarcoma （20.0%）, the differences were statistically significant （P 〈 0.01）. The expression of Ki-67 in common type uterine leiomyoma [（0.020＋0.009）/10 HPF] and cellular leiomyoma [（0.039＋0.011）/10 HPF] showed no significant difference （P 〉 0.05）. The expression of Ki-67in common type uterine leiomyoma and cellular leiomy-oma were apparently lower than that in the malignant potential undifferentiated leiomyoma [（0.231＋0.077）/10 HPF] and uterine fibroids sarcoma [（0.320~0.103）/ 10 HPF], the differences
出处
《中国医药导报》
CAS
2014年第33期43-46,50,F0003,共6页
China Medical Herald
基金
湖北省自然科学基金项目(编号2013CFC093)
