摘要
目的探讨前列地尔联合维生素C预防PCI术后造影剂肾病的临床效果。方法将125例接受PCI术的患者随机分为两组,对照组(62例)术前6 h静脉滴注生理盐水350 ml,术后连用3 d;研究组(63例)术前6 h静脉滴注前列地尔10μg+生理盐水100 ml及维生素C 3.0 g+生理盐水250 ml,术后连用3 d,观察术前1 d及术后第1、2、3天血肌酐及血β2-微球蛋白水平。结果研究组术后第1、2、3天的血肌酐为(96.61±16.06)、(99.75±16.98)、(93.24±15.36)μmol/L,分别低于对照组的(105.13±19.80)、(108.35±20.33)、(100.24±17.18)μmol/L(P<0.05)。研究组术后第1、2、3天的血β2-微球蛋白为(2.46±0.54)、(2.50±0.59)、(2.40±0.55)mg/L,分别低于对照组的(2.87±0.71)、(2.91±0.68)、(2.67±0.69)mg/L(P<0.05)。结论冠心病患者在择期PCI围术期联合应用前列地尔及维生素C可减少造影剂肾病的发生。
Objective To explore clinical efficacy of prostaglandin E1 combined with vitamin C in the prevention of contrast-induced nephropathy after PCI. Methods 125 patients with PCI were randomly divided into two groups.Intravenous infusion of normal saline 350 ml preoperative 6 hours was used in control group（62 cases）,intravenous infusion of alprostadil 10 μg and saline 100 ml,vitamin C 3.0 g and saline 250 ml preoperative 6 hours were used in study group（63 cases）,after the operation for 3 days.SCr and blood β2-M preoperative 1 day and postoperative 1,2,3-day were observed. Results SCr in atudy group postoperative 1,2,3-day was（96.61±16.06）,（99.75±16.98）,（93.24±15.36） μmol/L respectively,lower than that in control group [（105.13±19.80）,（108.35±20.33）,（100.24±17.18） μmol/L] respectively（P〈0.05）.Blood β2-M in atudy group postoperative 1,2,3-day was（2.46±0.54）,（2.50±0.59）,（2.40±0.55） mg/L respectively,lower than that in control group [（2.87±0.71）,（2.91±0.68）,（2.67±0.69） mg/L] respectively（P〈0.05）. Conclusion Infusion of prostaglandin E1 combined with vitamin C applied in patients underwent PCI can reduce the occurrence of contrast-induced nephropathy.
出处
《中国当代医药》
2014年第33期63-64,67,共3页
China Modern Medicine
关键词
经皮冠状动脉介入
前列地尔
维生素C
造影剂肾病
Percutaneous coronary intervention
Prostaglandin E1
Vitamin C
Contrast-induced nephropathy
