摘要
The total synthesis of a hydrated aurone derivative, 2-benzyl-4-methoxy-2,6-dihydroxybenzofuran-3（2H）-one, has been achieved for the first time with 2.4% overall yield. Using phloroglucinol as the starting material, the key steps included Friedel-Crafts acylation, Williamson synthesis, hydrogenolysis, aldol condensation, enolization and Rubottom oxidation.
本文以2.4%的总收率首次全合成了一个氢化橙酮衍生物,即4-甲氧基-2,6-二羟基-2-苄基-3(2H)-苯并呋喃酮。以间苯三酚为起始原料,该合成工作涉及的关键反应包括:傅克酰基化、Williamson关环、催化氢化、羟醛缩合、烯醇化以及Rubottom氧化反应等。
