摘要
目的:探讨肝脂肪变对慢性乙型肝炎患者抗病毒治疗效果的影响。方法:选取300例慢性乙型肝炎患者,根据肝细胞脂肪化程度的不同进行分组,脂肪变程度Ⅰ级100例为A组,脂肪变程度Ⅱ级100例为B组,脂肪变程度Ⅲ级100例为C组,3组患者均给予相同的抗病毒治疗措施,对比各组患者的抗病毒疗效及ALT复常情况。结果:纵向对比显示,治疗6个月各组患者疗效及ALT复常情况均显著优于治疗3个月(P<0.05);横向对比显示,同期A、B组患者的疗效均显著优于C组,而A组患者同时优于B组,差异具有统计学意义(P<0.05)。结论:肝脂肪变对慢性乙肝患者的抗病毒疗效造成不利影响,肝脂肪变可作为抗病毒治疗慢性乙肝的敏感指标。
Objective To explore influences of hepatic steatosis on effects of antiviral therapy for patients with chronic hepati-tis B. Methods： 300 cases with chronic hepatitis B were divided into three groups according to the different degrees of liver steatosis,steatosis grade I in 100 cases as A group, the steatosis grade II in 100 cases as B group, the steatosis grade III in 100 cases as Cgroup, all patients received the same antiviral treatment measures. The antiviral effects and ALT recovery situations of the three groupswere compared. Results： The longitudinal comparison showed that： the effects and ALT recovery situations 6 month after the treatmentfor eath group were significantly better than those 3 month after the treatment （P〈0. 05）. The horizontal comparison showed the effectsof A group and B group were significantly better than that of C group, and that of A group was better than that of B group （P〈0. 05）.Conclusions： Hepatic steatosis may affect the antiviral therapy on chronic hepatitis B patients, and can be used as a sensitive index ofantiviral therapy for chronic hepatitis B.
出处
《中国民康医学》
2014年第24期23-24,26,共3页
Medical Journal of Chinese People’s Health
关键词
慢性乙型肝炎
肝脂肪变
抗病毒治疗
Chronic hepatitis B
Hepatic steatosis
Antiviral therapy
