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抗感染类药物严重不良反应分析 被引量:8

Analysis of Serious Adverse Drug Reactions of Anti-infective Drugs
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摘要 目的分析北京市抗感染类药物的严重不良反应报告,为临床安全合理使用抗感染类药物提供参考。方法详细收集全国药品不良反应监测中心北京地区所有不良反应报告,按人群、药品、不良反应情况等方面进行统计、分析。结果 184例严重不良反应中,33例为新的严重不良反应,涉及喹诺酮类、头孢类、抗病毒类、抗真菌类、抗结核菌类药物。不良反应累及了人体各个器官,其中较常见的为全身症状、消化系统、血液系统、皮肤及其附件、泌尿生殖系统。结论使用抗感染药物应严格按药品使用说明书用药,加强用药过程监护,做好不良反应上报工作,促进临床合理用药。 OBJECTIVE To analyze the serious adverse drug reaction reports in Beijing during 2012 and provide reference to clinic about the reasonable use of anti-infective drugs. METHODS The total data from the information system of National Center for ADR Monitoring during the year of 2012 were statistically analyzed from the perspective of basic characteristics of the sufferers, the clinical presentations and the causing drugs of the ADRs etc. RESULTS Of the total of 184 serious adverse drug reactions, 33 were newly reported. The most common anti-infective drugs causing the serious ADRs were antivirals, quinolones, cephalosporins, anti-fungals and anti-TB drugs. The most common systems associated with serious ADRs in our study were whole body, gastrointestinal system, haematologic system, skin and accessories, and urogenital system. CONCLUSION In order to promote rational use of anti-infectives, it is very important to follow the drug instructions strictly, strengthen the monitoring of the medication process, and improve the ADR reporting.
出处 《中国药学杂志》 CAS CSCD 北大核心 2014年第22期2036-2038,共3页 Chinese Pharmaceutical Journal
关键词 抗感染药物 严重不良反应 合理用药 anti-infective drug serious adverse drug reaction rational drug use
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