摘要
慢性肾脏病5期患者常因继发性甲状旁腺功能亢进引起血管钙化、钙磷代谢障碍、肾性骨营养不良、纤维性骨炎等矿物质及骨代谢异常。近年研究表明这些并发症的发生与甲状旁腺素、成纤维细胞生长因子-23、骨碱性磷酸酶、骨保护素等大中分子物质蓄积、钙磷代谢障碍密切相关。现对上述物质的作用机制及目前的研究进展进行综述。目前治疗模式上主要集中在药物、手术、血液净化等,结果显示血液灌流串联血液透析滤过可促进矿物质及骨代谢异常的改善。
The patients with chronic kidney disease stage 5 are often complicated by secondary hyperparathyroidism,which cause metabolic abnormalities of minerals and bone,such as vascular calcification,calcium and phosphorus metabolism disorders,renal osteodystrophy,osteitis fibrosa.Recent studies show that these complications are associated with the disorders of calcium and phosphorus metabolism and the accumulation of middle or large molecules such as parathyroid hormone,fibroblast growth factor-23,bone alkaline phosphatase,osteoprotegerin.Research progress on these substances and the mechanisms is summarized in this paper.Current treatment has focused on drug,surgery,blood purification,etc,and he results has showed that hemoperfusion（HP）combined with hemodiafiltration（HDF） can promote and improve mineral and bone metabolism.
出处
《武警后勤学院学报（医学版）》
CAS
2014年第10期875-879,共5页
Journal of Logistics University of PAP（Medical Sciences）
