摘要
目的探讨急性缺血性卒中患者尿8-异前列腺素F2α（8-iso-prostaglandin F2α，8-iso-PGF2α）水平与颈动脉粥样硬化斑块稳定性的关系。方法连续纳入急性缺血性卒中患者，根据颈部血管超声检查结果分为无斑块组和斑块组，再将斑块组分为稳定斑块组和不稳定斑块组。采用酶联免疫吸附法检测尿8-iso—PGF2α水平。应用多变量logistic回归分析和Spearman相关分析探讨8-iso—PGF2α与颈动脉斑块的关系。结果共纳入150例急性缺血性卒中患者，其中104例存在颈动脉斑块（30例为稳定斑块，74例为不稳定斑块），46例无颈动脉斑块。斑块组尿8-iso—PGF2α水平[（86．45±6．20）ng／mmol肌酐对（45．70±6．19）ng／mmol肌酐；t=37．136，P=0．001]以及颈动脉内膜-中膜厚度（intima—media thickness，IMT）[（2．89±1．03）mm对（0．86±0．53）mm；t=3．518，P=0．002]显著性高于无斑块组。多变量logistic回归分析显示，尿8-iso—PGF2α水平[优势比（odds ratio，OR）1．183，95％可信区间（conmence interval，CI）1．087—1．276；P=0．001]和IMT（OR28．642，95％ CI8．276～137．231；P=0．001）是颈动脉斑块的独立危险因素；Pearson相关性分析显示，尿8-iso—PGF2α水平与颈动脉IMT无显著相关性（r=0．075，P=0．264）。不稳定斑块组尿8-iso—PGF2α水平显著高于稳定斑块组[（97．30±7．20）ng／mmol肌酐对（69．17±9．25）ng／mmol肌酐；t=16．506，P=0．001]，多变量logistic回归分析显示，8-iso—PGF2α水平（OR4．652，95％ CI 1．732～12．643；P=0．001）是斑块不稳定的独立危险因素。结论在缺血性卒中患者中，8-iso—PGF2α水平与颈动脉斑块的存在和不稳定性相关，其水平增高是颈动脉斑块不稳定的独立危险因素。
Objective To investigate the correlation between urinary 8-iso-prostaglandin F2α （8-iso- PGF2α） level and carotid atherosclerotic plaque stability in patients with acute ischemic stroke. Methods The patients with acute ischemic stroke were enrolled consecutively. According to the f＇mdings of carotid artery ultrasound, they were divided into either a non-plaque group or a plaque group, and then the plaque group was redivided into a stable plaque subgroup and an unstable plaque subgroup. Enzyme-linked immunosorbent assay （ELISA） was used to detect the levels of urinary 8-iso-PGF2α. Multivariate logistic regression analysis and Spearman correlation analysis were used to investigate the relationship between 8-iso-PGF2α and carotid artery plaques. Resulls A total of 150 patients with acute ischemic stroke were enrolled, including 104 had carotid artery plaque （30 were stable plaques and 74 were unstable plaques） and 46 had no carotid artery plaque. The urinary 8-iso-PGF2α level （ 86. 45 ± 6.20 ng/mmol creatinine vs. 45.70 ± 6. 19 ng/mmol creatinine; t =37. 136,P =0. 001） and intima-media thickness （IMT） （2. 89 ±1.03 mm vs. 0. 86 ±0. 53 mm; t =3. 518 ,P =0. 002） in the plaque group were significantly higher than those in the non-plaque group. Multivariate logistic regression analysis showed that urinary 8-iso-PGF2α level （odds ratio [OR] 1. 183,95% confidence interval [CI] 1.087-1.276; P=0.001） and IMT （OR 28.642, 95% CI 8. 276-137. 231; P =0. 001） were the independent risk factors for carotid artery plaque. Pearson correlation analysis showed that there was no significant correlation between urinary 8-iso-PGF2α level and carotid artery IMT （r=0. 075, P = 0. 264）. The urinary 8-iso-PGF2α level of the unstable plaque subgroup was significantly higher than that of the stable plaque subgroup （97.30 ± 7. 20 ng/mmol creatinine vs. 69. 17 ± 9.25 ng/mmol creatinine; t = 16. 506, P = 0. 001 ）. Multivariate logistic regression analysis showed that urinary 8-iso-PGF2α leve
出处
《国际脑血管病杂志》
北大核心
2014年第10期746-750,共5页
International Journal of Cerebrovascular Diseases
