摘要
目的：观察美托洛尔联合地高辛治疗缺血性心肌病合并心房颤动的临床效果。方法对80例缺血性心肌病合并心房颤动患者根据随机数字表法分为两组，对照组单纯使用地高辛进行治疗，观察组患者在对照组患者治疗方案基础上，加用美托洛尔，比较两组患者治疗前后超声心动图指标包括左心室舒张末内径（ LVEDD）、左室收缩末期内径（ LVESD）、每搏搏出量（ SV）和射血分数（ EF）改变情况、心率控制情况以及心房颤动的临床疗效。结果与治疗前比较，观察组LVEDD[（50．2±3．2） mm与（71．9±2．2） mm]、LVESD水平[（40．5±3．4）mm与（59．7±3．7）mm]均明显降低，SV[（69±5）mL与（39±4）mL]及EF水平[（59．7±8．7）％与（39．6±9．7）％]明显升高（t＝6．78、4．67、5．78、5．46，均P＜0．05）。观察组患者LVEDD、LVESD水平均明显低于对照组，SV以及EF水平明显高于对照组，差异有统计学意义（ t＝4．35、3．98、4．32、4.56，均P＜0．05）；经治疗，两组患者的心率水平均有下降，但观察组患者的静息期和活动期的心率水平[（71．2±8．9）次/min与（120．3±15．4）次/min]均明显低于同期对照组水平[（79．4±9．6）次/min与（140．2±13．3）次/min]，差异有统计学意义（t＝3．85、4．02，均P＜0．05）。结论美托洛尔联合地高辛治疗缺血性心脏病合并心房颤动临床效果显著，改善患者心脏功能更明显，降低了心率水平，临床总有效率更高，值得临床推广。
Objective To study the clinical effects of betaloc and digoxin in treatment of ischemic cardiomy-opathy with atrial fibrillation.Methods 80 patients were randomly divided into the observation group and control group,the control group were treated with digoxin,the observation group were received betaloc and digoxin.The ultra-sonic cardiogram changes,the heart rate control and the clinical effect on atrial fibrillation were compared.Results The level of LVEDD[（50.2 ±3.2）mm vs （71.9 ±2.2）mm] and LVESD[（40.5 ±3.4）mm vs （59.7 ±3.7）mm] for the two groups were lower those of after treatment,while the SV[（69 ±5）mL vs （39 ±4）mL] and EF[（59.7 ± 8.7）%vs （39.6 ±9.7）%] were higher than those of before（t=6.78,4.67,5.78,5.46,all P〈0.05）.The levels of these factors in the observation group were significantly changed when they were compared with the control （ t=4.35,3.98,4.32,4.56,all P〈0.05）.The heart rate in the two groups were lower than before,the resting stage [（71.2 ±8.9） vs （120.3 ±15.4）]and active stage[（79.4 ±9.6） vs （140.2 ±13.3）]of heart rate in the obser-vation group were significant lower than control（t=3.85,4.02,all P〈0.05）.Conclusion Betaloc and digoxin shows satisfactory clinical efficacy in the treatment of ischemic cardiomyopathy with atrial fibrillation, which can improve the cardiac function,decrease the heart rate.So it is worthy of clinical use.
出处
《中国基层医药》
CAS
2014年第22期3438-3440,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
心肌病
心房颤动
美托洛尔
地高辛
Cardiomyopathy
Atrial fibrillation
Betaloc
Digoxin
